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Name | Neurotensin receptor type 2 |
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Species | Rattus norvegicus (Rat) |
Gene | Ntsr2 |
Synonym | NTRL NTR2 NT2R NT-R-2 neurotensin receptor type 2 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 416 |
Amino acid sequence | METSSPWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFAFGTAGNALSVHVVLKARAGRPGRLRYHVLSLALSALLLLLVSMPMELYNFVWSHYPWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEVESADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFALPLALTAFLNGITVNHLMALYSQVPSASAQVSSIPSRLELLSEEGLLGFITWRKTLSLGVQASLVRHKDASQIRSLQHSAQVLRAIVAVYVICWLPYHARRLMYCYIPDDGWTNELYDFYHYFYMVTNTLFYVSSAVTPILYNAVSSSFRKLFLESLGSLCGEQHSLVPLPQEAPESTTSTYSFRLWGSPRNPSLGEIQV |
UniProt | Q63384 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5106 |
IUPHAR | 310 |
DrugBank | N/A |
Name | CHEMBL1172376 |
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Molecular formula | C41H70ClN9O8 |
IUPAC name | [(4S)-5-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxy-3-methylbutyl]amino]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-5-oxopentyl]-trimethylazanium;chloride |
Molecular weight | 852.516 |
Hydrogen bond acceptor | 10 |
Hydrogen bond donor | 8 |
XlogP | None |
Synonyms | N/A |
Inchi Key | DTAHXYZYSFSODV-QUWQNPMZSA-N |
Inchi ID | InChI=1S/C41H69N9O8.ClH/c1-25(2)23-31(39(57)58)47-37(55)33(41(4,5)6)48-35(53)30(24-27-16-18-28(51)19-17-27)46-36(54)32-15-11-21-49(32)38(56)29(14-10-20-44-40(42)43)45-34(52)26(3)13-12-22-50(7,8)9;/h16-19,25-26,29-33H,10-15,20-24H2,1-9H3,(H9-,42,43,44,45,46,47,48,51,52,53,54,55,57,58);1H/t26-,29-,30-,31-,32-,33+;/m0./s1 |
PubChem CID | 49798969 |
ChEMBL | CHEMBL1172376 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Kd | 23.31 nM | PMID20481538 | ChEMBL |
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