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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	fMet-Leu-Phe receptor
Species	Homo sapiens (Human)
Gene	FPR1
Synonym	NFPR N-formylpeptide chemoattractant receptor N-formyl peptide receptor FPR1 FPR formyl peptide receptor 1 fMLP receptor fMLF-R [ Show all ]
Disease	Inflammatory disease Peptic ulcer
Length	350
Amino acid sequence	METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProt	P21462
Protein Data Bank	N/A
GPCR-HGmod model	P21462
3D structure model	This predicted structure model is from GPCR-EXP P21462.
BioLiP	N/A
Therapeutic Target Database	T87831
ChEMBL	CHEMBL3359
IUPHAR	222
DrugBank	BE0000995

Ligand

Name	BDBM37655
Molecular formula	C22H17BrN2O4
IUPAC name	5-(3-bromophenyl)-4-(4-methylbenzoyl)-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione
Molecular weight	453.292
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	4.2
Synonyms	(4E)-5-(3-bromophenyl)-4-[hydroxy-(4-methylphenyl)methylidene]-1-(5-methyl-3-isoxazolyl)pyrrolidine-2,3-dione cid_5389438 (4E)-5-(3-bromophenyl)-1-(5-methyl-1,2-oxazol-3-yl)-4-[(4-methylphenyl)-oxidanyl-methylidene]pyrrolidine-2,3-dione (4E)-5-(3-bromophenyl)-4-[hydroxy(p-tolyl)methylene]-1-(5-methylisoxazol-3-yl)pyrrolidine-2,3-quinone
Inchi Key	AJCSMKLQIMMORL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H17BrN2O4/c1-12-6-8-14(9-7-12)20(26)18-19(15-4-3-5-16(23)11-15)25(22(28)21(18)27)17-10-13(2)29-24-17/h3-11,18-19H,1-2H3
PubChem CID	91896310
ChEMBL	N/A
IUPHAR	N/A
BindingDB	37655
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<66700.0 nM	N/A	BindingDB
Ki	<43700.0 nM	N/A	BindingDB

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