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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL1223966
Molecular formula	C31H34N6O
IUPAC name	N-[3-[1-[3-[[1-[(4-cyanophenyl)methyl]benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]acetamide
Molecular weight	506.654
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	4.9
Synonyms	AJAYHXDWVNTBJG-UHFFFAOYSA-N SCHEMBL4088575 BDBM50325959 N-(3-(1-(3-(1-(4-cyanobenzyl)-1H-benzo[d]imidazol-2-ylamino)propyl)piperidin-4-yl)phenyl)acetamide N-[3-(1-{3-[1-(4-Cyano-benzyl)-1H-benzoimidazol-2-ylamino]-propyl}-piperidin-4-yl)-phenyl]-acetamide
Inchi Key	AJAYHXDWVNTBJG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C31H34N6O/c1-23(38)34-28-7-4-6-27(20-28)26-14-18-36(19-15-26)17-5-16-33-31-35-29-8-2-3-9-30(29)37(31)22-25-12-10-24(21-32)11-13-25/h2-4,6-13,20,26H,5,14-19,22H2,1H3,(H,33,35)(H,34,38)
PubChem CID	11634823
ChEMBL	CHEMBL1223966
IUPHAR	N/A
BindingDB	50325959
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	38.0 nM	PMID20724156	BindingDB,ChEMBL

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