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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Motilin receptor
Species	Homo sapiens (Human)
Gene	MLNR
Synonym	GPR38 G protein-coupled receptor 38 G-protein coupled receptor 38 MTLR1 MTLR motilin receptor MOT-R [ Show all ]
Disease	Gastrointestinal disorders; Gastroesophageal reflux disease Irritable bowel syndrome Gastrointestinal disease Gastroesophageal reflux disease Gastric motility disorder Pain Dyspepsia Diarrhea Delayed gastric emptying; Gastroparesis Constipation Gastroparesis [ Show all ]
Length	412
Amino acid sequence	MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
UniProt	O43193
Protein Data Bank	N/A
GPCR-HGmod model	O43193
3D structure model	This predicted structure model is from GPCR-EXP O43193.
BioLiP	N/A
Therapeutic Target Database	T62306
ChEMBL	CHEMBL2203
IUPHAR	297
DrugBank	BE0003521

Ligand

Name	CHEMBL1078639
Molecular formula	C20H24N4O2
IUPAC name	N-(6-morpholin-4-ylpyridin-3-yl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7-carboxamide
Molecular weight	352.438
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	1.6
Synonyms	BDBM50415685
Inchi Key	DRNIAPGHNSFOCQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H24N4O2/c25-20(17-2-1-15-5-7-21-8-6-16(15)13-17)23-18-3-4-19(22-14-18)24-9-11-26-12-10-24/h1-4,13-14,21H,5-12H2,(H,23,25)
PubChem CID	46882627
ChEMBL	CHEMBL1078639
IUPHAR	N/A
BindingDB	50415685
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<12589.2 nM	PMID19804969	BindingDB,ChEMBL

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