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GPCR

NameNeuropeptides B/W receptor type 1
SpeciesHomo sapiens (Human)
GeneNPBWR1
SynonymG protein-coupled receptor 7
G-protein coupled receptor 7
GPR7
neuropeptides B/W receptor type 1
NPBW1 receptor
DiseaseN/A
Length328
Amino acid sequenceMDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProtP48145
Protein Data BankN/A
GPCR-HGmod modelP48145
3D structure modelThis predicted structure model is from GPCR-EXP P48145.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293293
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL2314295
Molecular formulaC24H21ClN2O3
IUPAC name5-chloro-2-(naphthalen-1-ylmethyl)-4-(4-propan-2-yloxyphenoxy)pyridazin-3-one
Molecular weight420.893
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP5.6
SynonymsSR-02000001172-1
BDBM50425572
SR-02000001172
Inchi KeyAJAMYCGPMGOZMX-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H21ClN2O3/c1-16(2)29-19-10-12-20(13-11-19)30-23-22(25)14-26-27(24(23)28)15-18-8-5-7-17-6-3-4-9-21(17)18/h3-14,16H,15H2,1-2H3
PubChem CID51003731
ChEMBLCHEMBL2314295
IUPHARN/A
BindingDB50425572
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50530.0 nMPMID23287738BindingDB,ChEMBL

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