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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	TAMSULOSIN
Molecular formula	C20H28N2O5S
IUPAC name	5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide
Molecular weight	408.513
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	2.7
Synonyms	DB00706 FT-0082894 KB-210214 Q-101875 (r)-tamsulosin Tamsolusin 5-[(2R)-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl]-2-methoxybenzene-1-sulfonamide Tamsulosine 814-EP2295426A1 AB1008589 ANW-58646 CS-2896 EBD36303 GTPL488 MLS006011810 (r)-(-)-tamsulosin SMR004703489 5-[2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxy-benzenesulfonamide Tamsulosinum [INN-Latin] 814-EP2305254A1 AJ-26680 BDBM50060964 D08560 Flomaxtra (TN) HSDB 7744 NCGC00167442-02 (r)-5-(2-(2-(2-ethoxyphenoxy)ethylamino)propyl)-2-methoxybenzenesulfonamide ST24035500 5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide Tamsulosina 814-EP2269989A1 YM-617 A835382 Amsulosin C07124 DRHKJLXJIQTDTD-OAHLLOKOSA-N FT-0601581 KS-00000L19 (-)-Tamsulosin RT-024223 106133-20-4 Tamsulon 5-[(2R)-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl]-2-methoxybenzenesulfonamide Tamsulosine [INN-French] 814-EP2295427A1 AC1L2V76 API0010078 CHEMBL836 CTK8B7795 Flomax Harnal-D MolPort-003-850-388 (R)-5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)-propyl)-2-methoxybenzenesulfonamide SR-05000001519 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide Tamsulosin (INN) 5-{(2R)-2-[(2-{[2-(ethyloxy)phenyl]oxy}ethyl)amino]propyl}-2-(methyloxy)benzenesulfonamide UNII-G3P28OML5I 814-EP2314587A1 AK-78696 Benzenesulfonamide, 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxy-, (R)- Flowmax HY-B0661 PubChem21320 (r)-5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-benzenesulfonamide STK626950 5-[(2R)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzene-sulfonamide Tamsulosina [INN-Spanish] 814-EP2270011A1 ZINC1530694 AB01275521-01 AN-10808 CHEBI:9398 DTXSID3023631 G3P28OML5I LS-31578 (-)-YM617 SCHEMBL34378 133T204 Tamsulon (TN) 5-[(2S)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide Tamsulosinum 814-EP2298767A1 ACT02653 AX8041134 Contiflo OD D05MBZ Flomax (TN) HMS2090P15 NCGC00167442-01 (R)-5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide SR-05000001519-1 5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxy-benzenesulfonamide Tamsulosin [INN:BAN] Urimax (TN) A801388 AKOS005266643 BIDD:GT0261 [ Show all ]
Inchi Key	DRHKJLXJIQTDTD-OAHLLOKOSA-N
Inchi ID	InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/t15-/m1/s1
PubChem CID	129211
ChEMBL	CHEMBL836
IUPHAR	488
BindingDB	50060964
DrugBank	DB00706
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	109.0 %	PMID10841797	ChEMBL
Ki	0.28 nM	PMID10841797	BindingDB,ChEMBL
Ratio	2.2 -	PMID10841797	ChEMBL

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