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Name | Metabotropic glutamate receptor 3 |
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Species | Rattus norvegicus (Rat) |
Gene | Grm3 |
Synonym | mGluR3 mGlu3 receptor GPRC1C glutamate receptor |
Disease | N/A for non-human GPCRs |
Length | 879 |
Amino acid sequence | MKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL |
UniProt | P31422 |
Protein Data Bank | 2e4u, 2e4v, 2e4w, 2e4x, 2e4y |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 2e4u. |
BioLiP | BL0086116,BL0086117, BL0086120,BL0086121, BL0086118,BL0086119, BL0086114,BL0086115, BL0086112,BL0086113 |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3067 |
IUPHAR | 291 |
DrugBank | N/A |
Name | CHEMBL544508 |
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Molecular formula | C13H15N3O6 |
IUPAC name | (2R,4R)-4-amino-1-[(2-nitrophenyl)methyl]pyrrolidine-2,4-dicarboxylic acid |
Molecular weight | 309.278 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 3 |
XlogP | -4.7 |
Synonyms | CHEMBL1193146 (2R)-1-(2-Nitrobenzyl)-4-aminopyrrolidine-2beta,4alpha-dicarboxylic acid BDBM50102116 (2R,4R)-4-amino-1-(2-nitrobenzyl)pyrrolidine-2,4-dicarboxylic acid dihydrochloride |
Inchi Key | DQMVLUXFRLQZJH-ZWNOBZJWSA-N |
Inchi ID | InChI=1S/C13H15N3O6/c14-13(12(19)20)5-10(11(17)18)15(7-13)6-8-3-1-2-4-9(8)16(21)22/h1-4,10H,5-7,14H2,(H,17,18)(H,19,20)/t10-,13-/m1/s1 |
PubChem CID | 10474978 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 50102116 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 6800.0 nM | PMID11459661 | BindingDB |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417