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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	2-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]pyrimidine
Molecular formula	C15H17ClN4
IUPAC name	2-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]pyrimidine
Molecular weight	288.779
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	2.6
Synonyms	AB00077338-01 MCULE-7509471462 Z46211313 2-[4-(2-chlorobenzyl)piperazino]pyrimidine BDBM114611 Oprea1_747867 2-{4-[(2-chlorophenyl)methyl]piperazin-1-yl}pyrimidine cid_750733 SR-01000201703-1 AC1LFARI MLS001008428 ZINC19536524 2-[4-[(2-chlorophenyl)methyl]-1-piperazinyl]pyrimidine SMR000495962 414876-66-7 HMS2845O04 SR-01000201703-3 2-[4-(2-chlorobenzyl)-1-piperazinyl]pyrimidine AKOS003971022 MolPort-002-140-765 CHEMBL1312518 SR-01000201703 [ Show all ]
Inchi Key	DQMBJOGFJSJHGY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H17ClN4/c16-14-5-2-1-4-13(14)12-19-8-10-20(11-9-19)15-17-6-3-7-18-15/h1-7H,8-12H2
PubChem CID	750733
ChEMBL	CHEMBL1312518
IUPHAR	N/A
BindingDB	114611
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	8912.5 nM	PubChem BioAssay data set	ChEMBL

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