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Name | Prostacyclin receptor |
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Species | Homo sapiens (Human) |
Gene | PTGIR |
Synonym | prostanoid IP receptor prostaglandin I2 receptor prostaglandin I2 (prostacyclin) receptor (IP) prostacyclin receptor PGI2 receptor [ Show all ] |
Disease | Solid tumours Pulmonary hypertension Medical abortion Pulmonary arterial hypertension Hypertension [ Show all ] |
Length | 386 |
Amino acid sequence | MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC |
UniProt | P43119 |
Protein Data Bank | N/A |
GPCR-HGmod model | P43119 |
3D structure model | This predicted structure model is from GPCR-EXP P43119. |
BioLiP | N/A |
Therapeutic Target Database | T99954 |
ChEMBL | CHEMBL1995 |
IUPHAR | 345 |
DrugBank | BE0000475 |
Name | FR-181157 |
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Molecular formula | C30H26NNaO4 |
IUPAC name | sodium;2-[3-[[(1S)-2-(4,5-diphenyl-1,3-oxazol-2-yl)cyclohex-2-en-1-yl]methyl]phenoxy]acetate |
Molecular weight | 487.531 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 0 |
XlogP | None |
Synonyms | Acetic acid, (3-(((1S)-2-(4,5-diphenyl-2-oxazolyl)-2-cyclohexen-1-yl)methyl)phenoxy)-, sodium salt 171046-15-4 SCHEMBL8057380 Acetic acid, (3-((2-(4,5-diphenyl-2-oxazolyl)-2-cyclohexen-1-yl)methyl)phenoxy)-, sodium salt, (S)- CHEMBL132589 [ Show all ] |
Inchi Key | DPECFBBZFTXROT-JIDHJSLPSA-M |
Inchi ID | InChI=1S/C30H27NO4.Na/c32-27(33)20-34-25-16-9-10-21(19-25)18-24-15-7-8-17-26(24)30-31-28(22-11-3-1-4-12-22)29(35-30)23-13-5-2-6-14-23;/h1-6,9-14,16-17,19,24H,7-8,15,18,20H2,(H,32,33);/q;+1/p-1/t24-;/m0./s1 |
PubChem CID | 23685469 |
ChEMBL | CHEMBL132589 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | Partition coefficient log P of this ligand is not available. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 60.0 nM | PMID16837197 | ChEMBL |
Ki | 54.0 nM | PMID15914004, PMID15935659, PMID15857112, PMID14643308, PMID15935660 | ChEMBL |
Ki | 60.0 nM | PMID16837197 | ChEMBL |
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