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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Cannabinoid receptor 1
Species	Rattus norvegicus (Rat)
Gene	Cnr1
Synonym	SKR6R Neuronal cannabinoid receptor Central cannabinoid receptor CB1R CB1 receptor CB1 CB-R Cann7 Cann6 Brain-type cannabinoid receptor THC receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	473
Amino acid sequence	MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
UniProt	P20272
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3571
IUPHAR	56
DrugBank	N/A

Ligand

Name	CHEMBL74909
Molecular formula	C22H36FNO
IUPAC name	(5Z,8Z,11Z,14Z)-N-(2-fluoroethyl)icosa-5,8,11,14-tetraenamide
Molecular weight	349.534
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	6.4
Synonyms	(5Z,8Z,11Z,14Z)-N-(2-fluoroethyl)icosa-5,8,11,14-tetraenamide Arachidonoyl-2'-Fluoroethylamide MolPort-039-138-932 N-(2-fluro-ethyl)arachidonoylamide 2'-Fluoro AEA SR-01000946637-1 Arachidonoyl 2'-fluoroethylamide Icosa-5,8,11,14-tetraenoic acid (2-fluoro-ethyl)-amide (0585) 1350AH BDBM50072757 N-(2-fluro-ethyl) arachidonoyl amine SCHEMBL14455464 ZINC13782506 (5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid (2-fluoro-ethyl)-amide arachidonoyl-(2'-fluoroethyl)amide LMFA08020055 166100-37-4 C22H36FNO N-(2-fluro-ethyl)-5Z,8Z,11Z,14Z-eicosatetraenoyl amine SR-01000946637 AC1NR2AA HMS3649B15 [ Show all ]
Inchi Key	DOGHEWWVBBVYEY-DOFZRALJSA-N
Inchi ID	InChI=1S/C22H36FNO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)24-21-20-23/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,24,25)/b7-6-,10-9-,13-12-,16-15-
PubChem CID	5283436
ChEMBL	CHEMBL74909
IUPHAR	N/A
BindingDB	50072757
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	8.6 nM	PMID10072686	BindingDB,ChEMBL
Ki	26.7 nM	PMID9876105	BindingDB,ChEMBL
Ki	4640.0 nM	PMID9876105	BindingDB,ChEMBL

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