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Name | Cannabinoid receptor 1 |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Cnr1 |
Synonym | SKR6R Neuronal cannabinoid receptor Central cannabinoid receptor CB1R CB1 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 473 |
Amino acid sequence | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL |
UniProt | P20272 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3571 |
IUPHAR | 56 |
DrugBank | N/A |
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GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
38 | CHEMBL12859 | C22H24N2O3 | 364.445 | 4 / 1 | 3.0 | Yes |
304 | CHEMBL2237755 | C16H12Cl3N3O | 368.642 | 3 / 1 | 4.1 | Yes |
834 | CHEMBL88548 | C18H15Cl3N4O | 409.695 | 3 / 2 | 5.2 | No |
940 | CHEMBL486958 | C23H21Cl3N4O | 475.798 | 4 / 0 | 7.2 | No |
1096 | CHEMBL231464 | C29H44O2 | 424.669 | 2 / 1 | 9.6 | No |
1173 | CHEMBL2064052 | C22H24O4 | 352.43 | 4 / 2 | 3.8 | Yes |
1451 | CHEMBL70952 | C25H24N2O | 368.48 | 2 / 1 | 5.0 | Yes |
2095 | CHEMBL2163952 | C30H32N2O3 | 468.597 | 4 / 1 | 5.9 | No |
2358 | CHEMBL519280 | C23H21Cl3N4O | 475.798 | 4 / 0 | 7.3 | No |
3012 | CHEMBL356213 | C21H39NO2 | 337.548 | 2 / 2 | 6.1 | No |
3014 | CHEMBL352931 | C21H39NO2 | 337.548 | 2 / 2 | 6.1 | No |
3045 | CHEMBL371328 | C26H26N2O2 | 398.506 | 3 / 1 | 5.1 | No |
3073 | CHEMBL2163572 | C29H38N4O3 | 490.648 | 6 / 1 | 4.2 | Yes |
3158 | AC1N0YGA | C3H7NO4S | 153.152 | 5 / 2 | -4.7 | Yes |
3476 | AC1LEVMS | C17H13NO2 | 263.296 | 3 / 0 | 3.7 | Yes |
3519 | CHEMBL263632 | C19H30O2 | 290.447 | 2 / 2 | 3.8 | Yes |
3647 | CHEMBL598095 | C25H23Cl3N6O2 | 545.849 | 5 / 2 | 5.4 | No |
4053 | CHEMBL149691 | C24H43NO2 | 377.613 | 3 / 3 | 6.1 | No |
4065 | AC1LP5MH | C19H16N2O2S | 336.409 | 4 / 0 | 4.1 | Yes |
4195 | CHEMBL2316259 | C25H34N2O2S | 426.619 | 4 / 1 | 6.4 | No |
4260 | CHEMBL2381791 | C29H36N4O2 | 472.633 | 4 / 1 | 6.4 | No |
4458 | CHEMBL2172461 | C11H20N2O4 | 244.291 | 5 / 2 | 0.4 | Yes |
4463 | CHEMBL558725 | C26H31BrClN3O | 516.908 | 4 / 1 | 8.6 | No |
5129 | CHEMBL68642 | C27H28N2O | 396.534 | 2 / 0 | 5.9 | No |
5191 | CHEMBL557736 | C26H24BrClN4 | 507.86 | 4 / 2 | 7.9 | No |
5339 | CHEMBL2010905 | C19H28N2O3S | 364.504 | 4 / 2 | 3.7 | Yes |
6035 | CHEMBL2316265 | C21H26N4O3 | 382.464 | 5 / 1 | 3.5 | Yes |
6476 | CHEMBL204387 | C24H28N2O5 | 424.497 | 5 / 3 | 4.7 | Yes |
6855 | AM 281 | C21H19Cl2IN4O2 | 557.213 | 4 / 1 | 5.3 | No |
7521 | JWH-182 | C27H29NO | 383.535 | 1 / 0 | 7.7 | No |
8254 | CHEMBL15779 | C19H16Cl3N3O2 | 424.706 | 3 / 2 | 4.7 | Yes |
8535 | SCHEMBL601645 | C22H27N3O | 349.478 | 2 / 0 | 4.6 | Yes |
8546 | CHEMBL161163 | C23H23BrCl2N4O2 | 538.267 | 4 / 1 | 6.5 | No |
8748 | 1-(1-Pentyl-1H-indol-3-yl)-2-phenylethanone | C21H23NO | 305.421 | 1 / 0 | 5.0 | Yes |
8851 | CHEMBL2381789 | C25H32N4O2 | 420.557 | 4 / 1 | 5.6 | No |
9099 | CHEMBL488031 | C26H34ClN3O | 440.028 | 2 / 1 | 5.9 | No |
9158 | CHEMBL158367 | C25H43NO2 | 389.624 | 2 / 1 | 6.4 | No |
9630 | CHEMBL2237740 | C17H12Cl3N3O2 | 396.652 | 4 / 0 | 5.5 | No |
9841 | CHEMBL2448132 | C26H26N2O2 | 398.506 | 3 / 0 | 4.6 | Yes |
9842 | CHEMBL2111962 | C26H26N2O2 | 398.506 | 3 / 0 | 4.6 | Yes |
9843 | CHEMBL319464 | C26H26N2O2 | 398.506 | 3 / 0 | 4.6 | Yes |
9920 | BDBM85802 | C18H17NO | 263.34 | 1 / 0 | 4.1 | Yes |
10022 | CHEMBL322112 | C29H36O2S2 | 480.725 | 4 / 1 | 8.4 | No |
10472 | CHEMBL470199 | C18H16O3 | 280.323 | 3 / 0 | 4.2 | Yes |
10501 | CHEMBL560747 | C25H30BrClN4S | 533.957 | 5 / 2 | 8.4 | No |
10891 | CHEMBL600682 | C31H28Cl3N7O | 620.963 | 5 / 0 | 7.2 | No |
10973 | CHEMBL1834522 | C18H11F6NO4S | 451.339 | 11 / 0 | 5.6 | No |
11007 | CHEMBL39460 | C25H37NO2 | 383.576 | 2 / 1 | 6.6 | No |
11124 | CHEMBL423602 | C25H43NO | 373.625 | 1 / 1 | 7.8 | No |
11268 | CHEMBL3221194 | C15H14N2OS | 270.35 | 2 / 0 | 3.2 | Yes |
442151 | CHEMBL2113102 | C23H36N4O | 384.568 | 3 / 1 | 6.6 | No |
11660 | CHEMBL2163571 | C28H35N3O3 | 461.606 | 5 / 1 | 5.2 | No |
12000 | CHEMBL472300 | C25H30Cl3N3O | 494.885 | 2 / 1 | 6.8 | No |
12205 | CHEMBL2172457 | C30H57NO4 | 495.789 | 4 / 1 | 9.8 | No |
12258 | CHEMBL519302 | C29H30BrClN2O | 537.926 | 1 / 1 | 7.3 | No |
12511 | CHEMBL600480 | C29H22Cl5N7O | 661.793 | 5 / 0 | 7.8 | No |
12781 | CHEMBL419138 | C20H19Cl3N4O | 437.749 | 3 / 2 | 6.1 | No |
12801 | CHEMBL2316278 | C26H33ClN4O2 | 469.026 | 4 / 1 | 6.3 | No |
12922 | CHEMBL1223179 | C25H18Cl2F3N7S | 576.423 | 9 / 0 | 6.9 | No |
13714 | CHEMBL606380 | C29H24BrCl2N7O | 637.363 | 5 / 0 | 6.6 | No |
13922 | CHEMBL1950330 | C25H33N3O | 391.559 | 2 / 0 | 4.1 | Yes |
14567 | CHEMBL2163930 | C24H28N2O3 | 392.499 | 4 / 1 | 4.3 | Yes |
16124 | CHEMBL274016 | C23H37NO | 343.555 | 1 / 1 | 6.7 | No |
16271 | CHEMBL487583 | C26H24Cl3N5O2 | 544.861 | 5 / 0 | 6.0 | No |
16417 | CHEMBL497557 | C25H25ClF3N5O | 503.954 | 8 / 1 | 4.9 | No |
16749 | CHEMBL346994 | C23H20Cl2N4O2S | 487.399 | 4 / 1 | 5.3 | No |
442322 | Ibipinabant | C23H20Cl2N4O2S | 487.399 | 4 / 1 | 5.3 | No |
442323 | 362519-49-1 | C23H20Cl2N4O2S | 487.399 | 4 / 1 | 5.3 | No |
16834 | BDBM82141 | C27H28N2O3 | 428.532 | 5 / 0 | 3.8 | Yes |
16890 | CHEMBL520472 | C25H26Cl3N3O2 | 506.852 | 3 / 1 | 8.0 | No |
17181 | CHEMBL589446 | C29H21Cl4N7O2 | 641.334 | 5 / 2 | 6.8 | No |
17745 | CHEMBL558801 | C24H23NO | 341.454 | 1 / 0 | 6.2 | No |
17830 | CHEMBL1223177 | C24H21Cl2N7S | 510.441 | 6 / 0 | 6.3 | No |
18282 | CHEMBL500927 | C19H12ClF4N5O3 | 469.781 | 11 / 1 | 3.7 | No |
18307 | CHEMBL483944 | C21H18Cl3N3O2 | 450.744 | 3 / 1 | 6.2 | No |
18365 | CHEMBL551869 | C16H9Cl2NO | 302.154 | 2 / 0 | 5.1 | No |
18412 | CHEMBL487173 | C25H22Cl3N5O3 | 546.833 | 6 / 0 | 6.1 | No |
18535 | CHEMBL563081 | C25H26Cl2N4O | 469.41 | 3 / 1 | 6.8 | No |
19271 | CHEMBL1269764 | C38H31Cl6N7O2 | 830.413 | 5 / 3 | 10.2 | No |
19457 | CHEMBL2316281 | C23H31N3O3 | 397.519 | 5 / 1 | 4.8 | Yes |
19522 | CHEMBL205685 | C23H26O2 | 334.459 | 2 / 2 | 6.1 | No |
20321 | CHEMBL422633 | C30H43NO3 | 465.678 | 3 / 3 | 7.7 | No |
20449 | CHEMBL3104360 | C24H34O4 | 386.532 | 4 / 1 | 5.3 | No |
20741 | CHEMBL2348465 | C28H38O3 | 422.609 | 3 / 1 | 7.4 | No |
21209 | CHEMBL272507 | C22H21Cl3N6 | 475.802 | 4 / 0 | 6.9 | No |
21412 | CHEMBL2112646 | C25H38O | 354.578 | 1 / 0 | 7.8 | No |
21638 | CHEMBL2348472 | C26H34O3 | 394.555 | 3 / 2 | 5.5 | No |
21682 | CHEMBL2237748 | C16H11Cl4N3 | 387.085 | 2 / 0 | 6.0 | No |
21965 | CHEMBL2381793 | C25H31ClN4O2 | 454.999 | 4 / 1 | 6.4 | No |
22332 | CHEMBL460307 | C28H41NO2 | 423.641 | 2 / 2 | 6.7 | No |
22418 | CHEMBL455557 | C10H7IO2 | 286.068 | 2 / 0 | 2.9 | Yes |
22425 | CHEMBL605757 | C25H23Cl3N6O | 529.85 | 4 / 1 | 6.5 | No |
23403 | CHEMBL485153 | C27H27Cl3N6O2 | 573.903 | 6 / 1 | 7.0 | No |
23450 | CHEMBL556686 | C24H24Cl2N4O | 455.383 | 3 / 1 | 6.4 | No |
24216 | CHEMBL486756 | C23H21Cl3N4O | 475.798 | 4 / 0 | 7.5 | No |
24298 | CHEMBL500655 | C24H26N4O3 | 418.497 | 5 / 1 | 3.4 | Yes |
24357 | CHEMBL519875 | C24H23Cl3N4O2 | 505.824 | 5 / 1 | 6.4 | No |
24423 | UNII-7W96Y4OF1O | C23H38O2 | 346.555 | 2 / 2 | 8.2 | No |
442628 | CHEMBL3354966 | C20H21F2N3O2 | 373.404 | 5 / 1 | 2.8 | Yes |
442634 | CHEMBL3354959 | C20H21F2N3O2 | 373.404 | 5 / 1 | 2.8 | Yes |
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