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Name | Cannabinoid receptor 1 |
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Species | Rattus norvegicus (Rat) |
Gene | Cnr1 |
Synonym | SKR6R Neuronal cannabinoid receptor Central cannabinoid receptor CB1R CB1 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 473 |
Amino acid sequence | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL |
UniProt | P20272 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3571 |
IUPHAR | 56 |
DrugBank | N/A |
Name | CHEMBL12859 |
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Molecular formula | C22H24N2O3 |
IUPAC name | (4-hydroxyphenyl)-[2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]methanone |
Molecular weight | 364.445 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 3.0 |
Synonyms | 3-(4-Hydroxybenzoyl)-2-methyl-1-[2-morpholinoethyl]-1H-indole |
Inchi Key | AABVOQWCRNMZEW-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C22H24N2O3/c1-16-21(22(26)17-6-8-18(25)9-7-17)19-4-2-3-5-20(19)24(16)11-10-23-12-14-27-15-13-23/h2-9,25H,10-15H2,1H3 |
PubChem CID | 10090179 |
ChEMBL | CHEMBL12859 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Inhibition | 15.0 % | PMID7636873 | ChEMBL |
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