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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Cannabinoid receptor 1
Species	Rattus norvegicus (Rat)
Gene	Cnr1
Synonym	SKR6R Neuronal cannabinoid receptor Central cannabinoid receptor CB1R CB1 receptor CB1 CB-R Cann7 Cann6 Brain-type cannabinoid receptor THC receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	473
Amino acid sequence	MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
UniProt	P20272
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3571
IUPHAR	56
DrugBank	N/A

Ligand

Name	CHEMBL1269764
Molecular formula	C38H31Cl6N7O2
IUPAC name	5-(4-chlorophenyl)-N-[2-[2-[[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carbonyl]amino]ethylamino]ethyl]-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide
Molecular weight	830.413
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	10.2
Synonyms	BDBM50328955 N,N''-(Iminodiethane-2,1-diyl)bis[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide]
Inchi Key	BAXHFHNXVCEHCG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C38H31Cl6N7O2/c1-21-33(48-50(31-13-11-27(41)19-29(31)43)35(21)23-3-7-25(39)8-4-23)37(52)46-17-15-45-16-18-47-38(53)34-22(2)36(24-5-9-26(40)10-6-24)51(49-34)32-14-12-28(42)20-30(32)44/h3-14,19-20,45H,15-18H2,1-2H3,(H,46,52)(H,47,53)
PubChem CID	49780575
ChEMBL	CHEMBL1269764
IUPHAR	N/A
BindingDB	50328955
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<10000.0 nM	PMID20845959	BindingDB,ChEMBL
Emax	-35.9 %	PMID20845959	ChEMBL

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