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Name | Cannabinoid receptor 1 |
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Species | Rattus norvegicus (Rat) |
Gene | Cnr1 |
Synonym | SKR6R Neuronal cannabinoid receptor Central cannabinoid receptor CB1R CB1 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 473 |
Amino acid sequence | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL |
UniProt | P20272 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3571 |
IUPHAR | 56 |
DrugBank | N/A |
Name | CHEMBL3104360 |
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Molecular formula | C24H34O4 |
IUPAC name | butyl 2-[(6aR,10aR)-1-hydroxy-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-3-yl]-2-methylpropanoate |
Molecular weight | 386.532 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 5.3 |
Synonyms | 1-Hydroxy-6,6,9,alpha,alpha-pentamethyl-6abeta,7,10,10aalpha-tetrahydro-6H-dibenzo[b,d]pyran-3-acetic acid butyl ester SCHEMBL15506165 |
Inchi Key | BCRQALSSNMYCDD-QZTJIDSGSA-N |
Inchi ID | InChI=1S/C24H34O4/c1-7-8-11-27-22(26)23(3,4)16-13-19(25)21-17-12-15(2)9-10-18(17)24(5,6)28-20(21)14-16/h9,13-14,17-18,25H,7-8,10-12H2,1-6H3/t17-,18-/m1/s1 |
PubChem CID | 76324747 |
ChEMBL | CHEMBL3104360 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 0.5 nM | PMID24286207 | ChEMBL |
Emax | 92.0 % | PMID24286207 | ChEMBL |
Ki | 0.3 nM | PMID24286207 | ChEMBL |
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