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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Motilin receptor
Species	Homo sapiens (Human)
Gene	MLNR
Synonym	GPR38 G protein-coupled receptor 38 G-protein coupled receptor 38 MTLR1 MTLR motilin receptor MOT-R [ Show all ]
Disease	Gastrointestinal disorders; Gastroesophageal reflux disease Irritable bowel syndrome Gastrointestinal disease Gastroesophageal reflux disease Gastric motility disorder Pain Dyspepsia Diarrhea Delayed gastric emptying; Gastroparesis Constipation Gastroparesis [ Show all ]
Length	412
Amino acid sequence	MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
UniProt	O43193
Protein Data Bank	N/A
GPCR-HGmod model	O43193
3D structure model	This predicted structure model is from GPCR-EXP O43193.
BioLiP	N/A
Therapeutic Target Database	T62306
ChEMBL	CHEMBL2203
IUPHAR	297
DrugBank	BE0003521

Ligand

Name	SCHEMBL1704164
Molecular formula	C26H33F3N4O
IUPAC name	2-[4-[[(3R)-3-methylpiperazin-1-yl]methyl]phenyl]-1-[4-[3-(trifluoromethyl)anilino]piperidin-1-yl]ethanone
Molecular weight	474.572
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	4.0
Synonyms	CHEMBL2364276
Inchi Key	DNXDIZDCMLZGSW-LJQANCHMSA-N
Inchi ID	InChI=1S/C26H33F3N4O/c1-19-17-32(14-11-30-19)18-21-7-5-20(6-8-21)15-25(34)33-12-9-23(10-13-33)31-24-4-2-3-22(16-24)26(27,28)29/h2-8,16,19,23,30-31H,9-15,17-18H2,1H3/t19-/m1/s1
PubChem CID	15984186
ChEMBL	CHEMBL2364276
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	2.512 nM	DOI: http://dx.doi.org/10.6019/CHEMBL2364262	ChEMBL

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