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GLASS

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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL466425
Molecular formula	C26H28F3N5O2
IUPAC name	2-(3,4-difluorophenyl)-N-[3-(6-fluorospiro[1H-furo[3,4-c]pyridine-3,4'-piperidine]-1'-yl)propyl]-N-methyl-2-pyrazol-1-ylacetamide
Molecular weight	499.538
Hydrogen bond acceptor	8
Hydrogen bond donor	0
XlogP	2.8
Synonyms	(+/-)-2-(3,4-difluorophenyl)-N-(3-(6-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4''-piperidine]-1''-yl)propyl)-N-methyl-2-(1H-pyrazol-1-yl)acetamide BDBM50258450 SCHEMBL13315579 2-(3,4-difluorophenyl)-N-(3-(6-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4''-piperidine]-1''-yl)propyl)-N-methyl-2-(1H-pyrazol-1-yl)acetamide
Inchi Key	AIRCJEQVEFTOIQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H28F3N5O2/c1-32(25(35)24(34-11-2-8-31-34)18-4-5-21(27)22(28)14-18)9-3-10-33-12-6-26(7-13-33)20-16-30-23(29)15-19(20)17-36-26/h2,4-5,8,11,14-16,24H,3,6-7,9-10,12-13,17H2,1H3
PubChem CID	10345845
ChEMBL	CHEMBL466425
IUPHAR	N/A
BindingDB	50258450
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	0.46 nM	PMID19403308	BindingDB,ChEMBL
IC50	1.3 nM	PMID19403308	BindingDB,ChEMBL

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