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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Homo sapiens (Human)
Gene	HTR6
Synonym	5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 5-HT6 [ Show all ]
Disease	Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis Cognitive disorders Unspecified Anxiety disorder Alzheimer disease; Dementia Alzheimer disease; Anxiety disorder Alzheimer disease [ Show all ]
Length	440
Amino acid sequence	MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
UniProt	P50406
Protein Data Bank	N/A
GPCR-HGmod model	P50406
3D structure model	This predicted structure model is from GPCR-EXP P50406.
BioLiP	N/A
Therapeutic Target Database	T16691
ChEMBL	CHEMBL3371
IUPHAR	11
DrugBank	BE0000945

Ligand

Name	N,N-DIMETHYLTRYPTAMINE
Molecular formula	C12H16N2
IUPAC name	2-(1H-indol-3-yl)-N,N-dimethylethanamine
Molecular weight	188.274
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	2.5
Synonyms	BRN 0138259 EINECS 200-508-4 Indole, 3-[2-(dimethylamino)ethyl]- N,N-Dimethyl-1H-indole-3-ethylamine NSC63795 [2-(1H-indol-3-yl)ethyl]dimethylamine 1H-Indole-3-ethanamine, N,N-dimethyl- (9CI) 2-(1H-indol-3-yl)-N,N-dimethylethylamine DIMETHYLTRYPTAMINE GTPL141 LS-82930 N,N-Dimethyltryptamine, >=97% (HPLC) UNII-WUB601BHAA (psychogenic) 2-(1H-indol-3-yl)-ethyl-dimethyl-amine 3-(2-DIMETHYLAMINOETHYL) INDOLE AC1L1LS3 D-5500 DMULVCHRPCFFGV-UHFFFAOYSA-N Indolalkylamine der N,N-dimethyl-1H-Indole-3-ethanamine NSC 63795 ZINC897457 2-(1H-Indol-3-yl)-N,N-dimethylethanamine # 3-[2- (dimethylamino)ethyl]-Indole AS-47089 C08302 DB01488 FCH838678 KB-296215 SCHEMBL335710 1H-INDOLE-3-ETHANAMINE,N,N-DIMETHYL 2-(3-Indolyl)ethyldimethylamine 61-50-7 CHEMBL12420 Dimethyltryptamine(DMT) HSDB 8017 MB00483 N,N-Dimethyltryptamine, free base WLN: T56 BMJ D2N1&1 2-(1H-INDOL-3-YL)-N,N-DIMETHYL-ETHANAMINE 3-(2-Dimethylaminoethyl)indole AKOS005446117 D0K1QS DTXSID60110053 Indole, 3-(2-(dimethylamino)ethyl)- N,N-dimethyl-1H-Indole-3-ethanamine (9CI) NSC-63795 [2-(1H-INDOL-3-YL)-ETHYL]-DIMETHYL-AMINE 1H-Indole-3-ethanamine, N,N-dimethyl- 2-(1H-indol-3-yl)-N,N-dimethylethanamine (ACD/Name 4.0) 3-[2-(dimethylamino)ethyl]indole BDBM50026868 CHEBI:28969 DEA No. 7435 FT-0667348 L001288 N,N-Dimethyltryptamine (DMT) solution, 1.0 mg/mL in methanol, certified reference material STK370594 (2-Indol-3-ylethyl)dimethylamine 1H-Indole-3-ethanamine,N,N-dimethyl- 3-(2-(dimethylamino)ethyl)-Indole 68677-25-8 CTK5B3344 DMT (psychogenic) InChI=1/C12H16N2/c1-14(2)8-7-10-9-13-12-6-4-3-5-11(10)12/h3-6,9,13H,7-8H2,1-2H MFCD00055989 N-(2-(1H-indol-3-yl)ethyl)-N,N-dimethylamine (ACD/Name 4.0) WUB601BHAA 061D507 2-(1H-Indol-3-yl)-N,N-dimethylethanamine 3-(dimethylaminoethyl)-indole AN-41827 [ Show all ]
Inchi Key	DMULVCHRPCFFGV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H16N2/c1-14(2)8-7-10-9-13-12-6-4-3-5-11(10)12/h3-6,9,13H,7-8H2,1-2H3
PubChem CID	6089
ChEMBL	CHEMBL12420
IUPHAR	141
BindingDB	50026868
DrugBank	DB01488
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
Ki	63.0957 nM	PMID8522988	IUPHAR
Ki	68.0 nM	PMID8522988	PDSP,BindingDB

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