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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Neuropeptides B/W receptor type 1
Species	Homo sapiens (Human)
Gene	NPBWR1
Synonym	G protein-coupled receptor 7 G-protein coupled receptor 7 GPR7 neuropeptides B/W receptor type 1 NPBW1 receptor
Disease	N/A
Length	328
Amino acid sequence	MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProt	P48145
Protein Data Bank	N/A
GPCR-HGmod model	P48145
3D structure model	This predicted structure model is from GPCR-EXP P48145.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293293
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SR-02000000447
Molecular formula	C18H15ClN2O3
IUPAC name	5-chloro-4-(4-methoxyphenoxy)-2-(3-methylphenyl)pyridazin-3-one
Molecular weight	342.779
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.9
Synonyms	CHEMBL1728794 SR-02000000447-1 5-chloro-4-(4-methoxyphenoxy)-2-(3-methylphenyl)pyridazin-3-one BDBM75917 cid_46835805 5-chloranyl-4-(4-methoxyphenoxy)-2-(3-methylphenyl)pyridazin-3-one 5-chloro-4-(4-methoxyphenoxy)-2-(m-tolyl)pyridazin-3-one 5-chloro-4-(4-methoxyphenoxy)-2-(3-methylphenyl)-3-pyridazinone [ Show all ]
Inchi Key	DMMBVVPSIDEESL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H15ClN2O3/c1-12-4-3-5-13(10-12)21-18(22)17(16(19)11-20-21)24-15-8-6-14(23-2)7-9-15/h3-11H,1-2H3
PubChem CID	46835805
ChEMBL	CHEMBL1728794
IUPHAR	N/A
BindingDB	75917
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	570.0 nM	PMID23079522	BindingDB,ChEMBL
IC50	572.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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