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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	SR-02000000453
Molecular formula	C21H15ClN2O3
IUPAC name	5-chloro-4-(4-methoxyphenoxy)-2-naphthalen-1-ylpyridazin-3-one
Molecular weight	378.812
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.8
Synonyms	5-chloro-4-(4-methoxyphenoxy)-2-(1-naphthalenyl)-3-pyridazinone CHEMBL1721648 SR-02000000453-1 5-chloro-4-(4-methoxyphenoxy)-2-(1-naphthyl)pyridazin-3-one BDBM75923 5-chloranyl-4-(4-methoxyphenoxy)-2-naphthalen-1-yl-pyridazin-3-one cid_46835792 5-chloro-4-(4-methoxyphenoxy)-2-naphthalen-1-ylpyridazin-3-one [ Show all ]
Inchi Key	DMCSOBVBUJXKJS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H15ClN2O3/c1-26-15-9-11-16(12-10-15)27-20-18(22)13-23-24(21(20)25)19-8-4-6-14-5-2-3-7-17(14)19/h2-13H,1H3
PubChem CID	46835792
ChEMBL	CHEMBL1721648
IUPHAR	N/A
BindingDB	75923
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	8400.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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