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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Neuropeptides B/W receptor type 1
Species	Homo sapiens (Human)
Gene	NPBWR1
Synonym	G protein-coupled receptor 7 G-protein coupled receptor 7 GPR7 neuropeptides B/W receptor type 1 NPBW1 receptor
Disease	N/A
Length	328
Amino acid sequence	MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProt	P48145
Protein Data Bank	N/A
GPCR-HGmod model	P48145
3D structure model	This predicted structure model is from GPCR-EXP P48145.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293293
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SR-02000000453
Molecular formula	C21H15ClN2O3
IUPAC name	5-chloro-4-(4-methoxyphenoxy)-2-naphthalen-1-ylpyridazin-3-one
Molecular weight	378.812
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.8
Synonyms	5-chloro-4-(4-methoxyphenoxy)-2-(1-naphthyl)pyridazin-3-one SR-02000000453-1 BDBM75923 5-chloranyl-4-(4-methoxyphenoxy)-2-naphthalen-1-yl-pyridazin-3-one cid_46835792 5-chloro-4-(4-methoxyphenoxy)-2-naphthalen-1-ylpyridazin-3-one 5-chloro-4-(4-methoxyphenoxy)-2-(1-naphthalenyl)-3-pyridazinone CHEMBL1721648 [ Show all ]
Inchi Key	DMCSOBVBUJXKJS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H15ClN2O3/c1-26-15-9-11-16(12-10-15)27-20-18(22)13-23-24(21(20)25)19-8-4-6-14-5-2-3-7-17(14)19/h2-13H,1H3
PubChem CID	46835792
ChEMBL	CHEMBL1721648
IUPHAR	N/A
BindingDB	75923
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	359.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL
IC50	360.0 nM	PMID23079522	BindingDB,ChEMBL

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