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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Vasopressin V2 receptor
Species	Rattus norvegicus (Rat)
Gene	Avpr2
Synonym	AVPR V2 Antidiuretic hormone receptor ADHR Renal-type arginine vasopressin receptor V2 receptor V2R DIR3 [ Show all ]
Disease	N/A for non-human GPCRs
Length	371
Amino acid sequence	MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
UniProt	Q00788
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3766
IUPHAR	368
DrugBank	N/A

Ligand

Name	CHEMBL334082
Molecular formula	C27H29N3O3
IUPAC name	N-[4-[5-(dimethylamino)-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]phenyl]-2-methoxybenzamide
Molecular weight	443.547
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.1
Synonyms	N-[4-[[[2,3,4,5-Tetrahydro-5-(dimethylamino)-1H-1-benzazepin]-1-yl]carbonyl]phenyl]-2-methoxybenzamide BDBM50052946 N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-2-methoxy-benzamide
Inchi Key	DLZVHVLNGKHMAT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H29N3O3/c1-29(2)23-12-8-18-30(24-11-6-4-9-21(23)24)27(32)19-14-16-20(17-15-19)28-26(31)22-10-5-7-13-25(22)33-3/h4-7,9-11,13-17,23H,8,12,18H2,1-3H3,(H,28,31)
PubChem CID	10599369
ChEMBL	CHEMBL334082
IUPHAR	N/A
BindingDB	50052946
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	77.0 nM	PMID8784453	BindingDB
IC50	77.0 nM	PMID8784453	ChEMBL

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