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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Urotensin-2 receptor
Species	Homo sapiens (Human)
Gene	UTS2R
Synonym	urotensin II receptor UT receptor UR-II-R UR-2-R UII-R1 SENR (sensory epithelial neuropeptide-like receptor) GPR14 G-protein coupled receptor 14 G protein-coupled receptor 14 UTR2 [ Show all ]
Disease	Asthma Diabetic nephropathy Renal failure
Length	389
Amino acid sequence	MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA
UniProt	Q9UKP6
Protein Data Bank	N/A
GPCR-HGmod model	Q9UKP6
3D structure model	This predicted structure model is from GPCR-EXP Q9UKP6.
BioLiP	N/A
Therapeutic Target Database	T49072
ChEMBL	CHEMBL3764
IUPHAR	365
DrugBank	N/A

Ligand

Name	CHEMBL2372904
Molecular formula	C61H80N12O18S2
IUPAC name	(4S)-4-amino-5-[[(2S,3R)-1-[(2R)-2-[[(2S)-3-carboxy-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
Molecular weight	1333.5
Hydrogen bond acceptor	21
Hydrogen bond donor	18
XlogP	-1.9
Synonyms	N/A
Inchi Key	DLYYRONXNNKUJL-JYDKZSAOSA-N
Inchi ID	InChI=1S/C61H80N12O18S2/c1-30(2)49(61(90)91)71-58(87)45(29-93)70-55(84)40(24-34-16-18-36(75)19-17-34)65-51(80)31(3)64-53(82)42(25-35-27-63-39-14-9-8-13-37(35)39)67-54(83)41(23-33-11-6-5-7-12-33)66-57(86)44(28-92)69-56(85)43(26-48(78)79)68-59(88)46-15-10-22-73(46)60(89)50(32(4)74)72-52(81)38(62)20-21-47(76)77/h5-9,11-14,16-19,27,30-32,38,40-46,49-50,63,74-75,92-93H,10,15,20-26,28-29,62H2,1-4H3,(H,64,82)(H,65,80)(H,66,86)(H,67,83)(H,68,88)(H,69,85)(H,70,84)(H,71,87)(H,72,81)(H,76,77)(H,78,79)(H,90,91)/t31-,32+,38-,40-,41-,42-,43-,44-,45-,46+,49-,50-/m0/s1
PubChem CID	73350313
ChEMBL	CHEMBL2372904
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	14800.0 nM	PMID11960491	ChEMBL

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