You can:
Name | Muscarinic acetylcholine receptor M2 |
---|---|
Species | Homo sapiens (Human) |
Gene | CHRM2 |
Synonym | cholinergic receptor AChR M2 M2 muscarinic acetylcholine receptor M2 receptor Chrm-2 [ Show all ] |
Disease | Urinary incontinence Heart failure Nausea; Addiction Parkinson's disease Peptic ulcer [ Show all ] |
Length | 466 |
Amino acid sequence | MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR |
UniProt | P08172 |
Protein Data Bank | 5zkc, 4mqs, 4mqt, 5yc8, 5zk3, 5zkb, 5zk8 |
GPCR-HGmod model | P08172 |
3D structure model | This structure is from PDB ID 5zkc. |
BioLiP | BL0433341, BL0433216, BL0263147, BL0263146, BL0263145, BL0433339, BL0433340, BL0433338 |
Therapeutic Target Database | T46185 |
ChEMBL | CHEMBL211 |
IUPHAR | 14 |
DrugBank | BE0000560 |
Name | BDBM86295 |
---|---|
Molecular formula | C12H16N3O2+ |
IUPAC name | 2-[4-(2,3-dimethylimidazol-3-ium-1-yl)but-2-ynyl]-1,2-oxazolidin-3-one |
Molecular weight | 234.279 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 0 |
XlogP | 0.0 |
Synonyms | PDSP2_001319 2-[4-(2,3-Dimethyl-1H-imidazolium-1-yl)-2-butynyl]isoxazolidin-3-one iodide PDSP1_001335 |
Inchi Key | AILVCKQCTVDJPU-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C12H16N3O2/c1-11-13(2)8-9-14(11)6-3-4-7-15-12(16)5-10-17-15/h8-9H,5-7,10H2,1-2H3/q+1 |
PubChem CID | 23844146 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 86295 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 275.42 nM | PMID13679167 | BindingDB |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417