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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Free fatty acid receptor 1
Species	Homo sapiens (Human)
Gene	FFAR1
Synonym	FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40 FFA1 receptor
Disease	Type 2 diabetes Non-insulin dependent diabetes Diabetes
Length	300
Amino acid sequence	MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProt	O14842
Protein Data Bank	5tzy, 5tzr
GPCR-HGmod model	O14842
3D structure model	This structure is from PDB ID 5tzy.
BioLiP	BL0380462, BL0380463, BL0380464
Therapeutic Target Database	T25608
ChEMBL	CHEMBL4422
IUPHAR	225
DrugBank	BE0000688

Ligand

Name	DIDODECANOYLPHLOROGLUCINOL
Molecular formula	C30H50O5
IUPAC name	1-(3-dodecanoyl-2,4,6-trihydroxyphenyl)dodecan-1-one
Molecular weight	490.725
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	11.6
Synonyms	CHEMBL470757 1,1'-(2,4,6-trihydroxy-1,3-phenylene)bis-1-dodecanone MolPort-044-550-959 BDBM50256011 1,1''-(2,4,6-trihydroxy-1,3-phenylene)didodecan-1-one D0J2EE 144337-28-0 SCHEMBL9188500 1,1'-(2,4,6-Trihydroxy-1,3-phenylene)bis(dodecan-1-one) ZINC44417494 [ Show all ]
Inchi Key	AIKYCZDMJFKXLS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C30H50O5/c1-3-5-7-9-11-13-15-17-19-21-24(31)28-26(33)23-27(34)29(30(28)35)25(32)22-20-18-16-14-12-10-8-6-4-2/h23,33-35H,3-22H2,1-2H3
PubChem CID	9957245
ChEMBL	CHEMBL470757
IUPHAR	N/A
BindingDB	50256011
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Activity	100.2 %	PMID18993064	ChEMBL
EC50	70.0 nM	PMID18993064	BindingDB,ChEMBL
EC50	75.86 nM	PMID18993064	ChEMBL
FC	2.326 -	PMID18993064	ChEMBL

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