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Name | D(2) dopamine receptor |
---|---|
Species | Bos taurus (Bovine) |
Gene | DRD2 |
Synonym | Dopamine D2 receptor |
Disease | N/A for non-human GPCRs |
Length | 444 |
Amino acid sequence | MDPLNLSWYDDDPESRNWSRPFNGSEGKADRPPYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPMLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRANLKAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKTVNPKIAKIFEIQSMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC |
UniProt | P20288 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3998 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL11592 |
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Molecular formula | C26H38N2O4 |
IUPAC name | 8-[4-[(5-methoxy-3,4-dihydro-2H-chromen-3-yl)-propylamino]butyl]-8-azaspiro[4.5]decane-7,9-dione |
Molecular weight | 442.6 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 0 |
XlogP | 4.6 |
Synonyms | PDSP2_000057 BDBM82368 8-[4-[Propyl(5-methoxychroman-3-yl)amino]butyl]-8-azaspiro[4.5]decane-7,9-dione NSC_121851 AC1L3TIS [ Show all ] |
Inchi Key | DLLULNTXJPATBC-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C26H38N2O4/c1-3-13-27(20-16-21-22(31-2)9-8-10-23(21)32-19-20)14-6-7-15-28-24(29)17-26(18-25(28)30)11-4-5-12-26/h8-10,20H,3-7,11-19H2,1-2H3 |
PubChem CID | 121852 |
ChEMBL | CHEMBL11592 |
IUPHAR | N/A |
BindingDB | 82368 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 10.0 nM | PMID8863806, PMID7912735 | BindingDB,ChEMBL |
IC50 | 20.0 nM | PMID8863806 | BindingDB,ChEMBL |
IC50 | 3000.0 nM | PMID7912735 | BindingDB |
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