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Name | Gastrin-releasing peptide receptor |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Grpr |
Synonym | BB2 BB2 receptor gastrin-releasing peptide receptor GRP-preferring bombesin receptor GRP-R |
Disease | N/A for non-human GPCRs |
Length | 384 |
Amino acid sequence | MDPNNCSHLNLEVDPFLSCNNTFNQTLNPPKMDNWFHPGIIYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPFHVKDTNQTFISCAPYPHSNELHPKIHSMASFLVFYIIPLSIISVYYYFIARNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFITSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPSLLNRSHSTGRSTTCMTSFKSTNPSATFSLINGNICHEGYV |
UniProt | P52500 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4280 |
IUPHAR | 39 |
DrugBank | N/A |
Name | CHEMBL265894 |
---|---|
Molecular formula | C56H78N16O10S |
IUPAC name | (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[(2-aminoacetyl)amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-N-[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]-formylamino]-4-methylpentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]-3-methylbutanamide |
Molecular weight | 1167.4 |
Hydrogen bond acceptor | 14 |
Hydrogen bond donor | 13 |
XlogP | 1.5 |
Synonyms | N/A |
Inchi Key | AIKLPWGJFUOHKA-UCYKYQRWSA-N |
Inchi ID | InChI=1S/C56H78N16O10S/c1-32(2)18-39(28-72(31-73)46(50(58)76)16-17-83-6)66-53(79)44(21-37-25-59-29-63-37)68-48(75)27-62-56(82)49(33(3)4)71-51(77)34(5)65-52(78)43(20-36-24-61-41-15-11-10-14-40(36)41)69-55(81)45(22-38-26-60-30-64-38)70-54(80)42(67-47(74)23-57)19-35-12-8-7-9-13-35/h7-15,24-26,29-34,39,42-46,49,61H,16-23,27-28,57H2,1-6H3,(H2,58,76)(H,59,63)(H,60,64)(H,62,82)(H,65,78)(H,66,79)(H,67,74)(H,68,75)(H,69,81)(H,70,80)(H,71,77)/t34-,39-,42+,43-,44-,45-,46-,49-/m0/s1 |
PubChem CID | 44361865 |
ChEMBL | CHEMBL265894 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Release | 3.7 % | PMID1469698 | ChEMBL |
Release | 10.4 % | PMID1469698 | ChEMBL |
Release | 11.6 % | PMID1469698 | ChEMBL |
Release | 13.3 % | PMID1469698 | ChEMBL |
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