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Name | D(2) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD2 |
Synonym | dopamine receptor 2 Dopamine D2 receptor D2R D2A and D2B D2(415) and D2(444) [ Show all ] |
Disease | Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease [ Show all ] |
Length | 443 |
Amino acid sequence | MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC |
UniProt | P14416 |
Protein Data Bank | 6cm4, 6c38 |
GPCR-HGmod model | P14416 |
3D structure model | This structure is from PDB ID 6cm4. |
BioLiP | BL0408379, BL0403379 |
Therapeutic Target Database | T67162 |
ChEMBL | CHEMBL217 |
IUPHAR | 215 |
DrugBank | BE0000756 |
Name | CHEMBL168541 |
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Molecular formula | C21H24N4O |
IUPAC name | (4S)-2-phenyl-4-[(4-phenylpiperazin-1-yl)methyl]-4,5-dihydro-1H-pyrimidin-6-one |
Molecular weight | 348.45 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 2.3 |
Synonyms | (6S)-2-Phenyl-6beta-(4-phenylpiperazinomethyl)-3,4,5,6-tetrahydropyrimidine-4-one BDBM50124196 (S)-2-Phenyl-6-(4-phenyl-piperazin-1-ylmethyl)-5,6-dihydro-3H-pyrimidin-4-one |
Inchi Key | DKXYPAWNMBQJBN-SFHVURJKSA-N |
Inchi ID | InChI=1S/C21H24N4O/c26-20-15-18(22-21(23-20)17-7-3-1-4-8-17)16-24-11-13-25(14-12-24)19-9-5-2-6-10-19/h1-10,18H,11-16H2,(H,22,23,26)/t18-/m0/s1 |
PubChem CID | 44381276 |
ChEMBL | CHEMBL168541 |
IUPHAR | N/A |
BindingDB | 50124196 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 6400.0 nM | PMID12617906 | BindingDB,ChEMBL |
Ki | 18000.0 nM | PMID12617906 | BindingDB,ChEMBL |
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