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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Type-1B angiotensin II receptor
Species	Rattus norvegicus (Rat)
Gene	Agtr1b
Synonym	Angiotensin II type-1B receptor AT1B AT3
Disease	N/A for non-human GPCRs
Length	359
Amino acid sequence	MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
UniProt	P29089
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL263
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL130828
Molecular formula	C25H25N3O2
IUPAC name	2-[4-[(6-amino-2-butylbenzimidazol-1-yl)methyl]phenyl]benzoic acid
Molecular weight	399.494
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	5.2
Synonyms	4'-[(6-amino-2-n-butyl-benzimidazol-1-yl)methyl]biphenyl-2-carboxylic acid SCHEMBL8395423 4''-(6-Amino-2-butyl-benzoimidazol-1-ylmethyl)-biphenyl-2-carboxylic acid 4'-[[2-Butyl-6-amino-1H-benzimidazol-1-yl]methyl]-1,1'-biphenyl-2-carboxylic acid BDBM50043272 4'-[(6-amino-2-n-butyl-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylic acid DJQPXPQWGMZSJC-UHFFFAOYSA-N 4'-[[2-n-butyl-6-aminobenzimidazol-1-yl]-methyl]biphenyl-2-carboxylic acid [ Show all ]
Inchi Key	DJQPXPQWGMZSJC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H25N3O2/c1-2-3-8-24-27-22-14-13-19(26)15-23(22)28(24)16-17-9-11-18(12-10-17)20-6-4-5-7-21(20)25(29)30/h4-7,9-15H,2-3,8,16,26H2,1H3,(H,29,30)
PubChem CID	10363552
ChEMBL	CHEMBL130828
IUPHAR	N/A
BindingDB	50043272
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	540.0 nM	PMID8258826	BindingDB,ChEMBL

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