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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 Niacin receptor 1 G-protein coupled receptor 109A G-protein coupled receptor HM74A HCA2 receptor [ Show all ]
Disease	Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis Arteriosclerosis Acute ischemic stroke [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	ACIPIMOX
Molecular formula	C6H6N2O3
IUPAC name	5-methyl-4-oxidopyrazin-4-ium-2-carboxylic acid
Molecular weight	154.125
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	-1.0
Synonyms	M2053 5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid Nedios 51037-30-0 Pyrazinecarboxylic acid, 5-methyl-, 4-oxide AB2000302 STK711089 ACMC-209krk ZINC1481960 BC200650 CC-23736 D07190 EINECS 256-928-3 K 9321 2-CARBOXY-5-METHYLPYRAZINE 4-OXIDE 5-Carboxy-2-methylpyrazine 1-oxide MolPort-002-507-946 5-Methyl-4-oxy-pyrazine-2-carboxylic acid Olbemox AB0017262 SC-04926 Tox21_111868 ANW-31182 BR-72905 DJQOOSBJCLSSEY-UHFFFAOYSA-N GTPL1596 K9AY9IR2SD LS-127587 5-methyl-4-oxidanidyl-pyrazin-4-ium-2-carboxylic acid NCGC00160519-02 5-Methylpyrazinecarboxylic acid 4-oxide Pharmakon1600-01504831 AB01274727_03 SR-05000001505-1 Acipimox [BAN:INN] UNII-K9AY9IR2SD BBL009924 C6H6N2O3 CS-2295 DSSTox_RID_81433 HMS3713L18 2-Pyrazinecarboxylic acid, 5-methyl-, 4-oxide MB01535 5-methyl-4-oxido-pyrazin-4-ium-2-carboxylic acid NSC-759818 51037-30-0,76958-97-9(sodiumsalt) RL03875 AC-009 SW199084-2 AKOS005530658 BCP28412 CCG-213957 D0S1NZ FCH842455 K-9321 5-Methyl-2-pyrazincarbonsaeure-4-oxid Monted 5-methylpyrazine-2-carboxylic acid 4-oxide Olbetam AB01274727-01 SCHEMBL48922 Acipimox (5-Methylpyrazinecarboxylic acid 4-oxide) Tox21_112498 API0001368 BRD-K63736853-001-01-4 CHEMBL345714 DSSTox_CID_26202 HMS2090G05 KB-198086 M-3132 5-METHYL-4-OXIDE-2-PYRAZINECARBOXYLIC ACID NCGC00160519-03 PubChem8885 AB01274727_04 SR-05000001505-2 Acipimoxum [INN-Latin] W-105921 BB_SC-02776 CAS-51037-30-0 CTK8B1789 DTXSID2046202 HY-B0283 2-carboxy-5-methyl-pyrazine-4-oxide 4-OXO-5-METHYLPYRAZINE-2-CARBOXYLIC ACID MFCD00865757 5-methyl-4-oxidopyrazin-4-ium-2-carboxylic acid NSC759818 A828409 s1806 AC1NSJSE TC-063864 AN-16205 BDBM50208130 CHEBI:94688 DB09055 FT-0601589 K-9321;Olbemox;Olbetam KS-000013DM 5-Methyl-2-pyrazinecarboxylic acid 4-oxide NCGC00160519-01 5-Methylpyrazine-2-carboxylicAcid4-Oxide P888 AB01274727-02 SR-05000001505 Acipimox (INN/BAN) Tox21_112805 AS-15565 BRN 0777471 CO-006 DSSTox_GSID_46202 HMS3655A14 [ Show all ]
Inchi Key	DJQOOSBJCLSSEY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H6N2O3/c1-4-2-7-5(6(9)10)3-8(4)11/h2-3H,1H3,(H,9,10)
PubChem CID	5310993
ChEMBL	CHEMBL345714
IUPHAR	1596
BindingDB	50208130
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	2510.0 - 6310.0 nM	PMID12522134, PMID12646212	IUPHAR
EC50	5300.0 nM	PMID17358052	BindingDB,ChEMBL

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