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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	SMR000004969
Molecular formula	C26H29ClN6O3
IUPAC name	[4-[(1-benzyltetrazol-5-yl)-(4-ethoxyphenyl)methyl]piperazin-1-yl]-(furan-2-yl)methanone;hydrochloride
Molecular weight	509.007
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	None
Synonyms	MLS000888356 {4-[(1-Benzyl-1H-tetrazol-5-yl)-(4-ethoxy-phenyl)-methyl]-piperazin-1-yl}-furan-2-yl-methanone CHEMBL1415721 AC1O7ETK MLS000031099 [4-[(1-benzyltetrazol-5-yl)-(4-ethoxyphenyl)methyl]piperazin-1-yl]-(furan-2-yl)methanone hydrochloride [ Show all ]
Inchi Key	AAXMDUFSNAUODX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H28N6O3.ClH/c1-2-34-22-12-10-21(11-13-22)24(25-27-28-29-32(25)19-20-7-4-3-5-8-20)30-14-16-31(17-15-30)26(33)23-9-6-18-35-23;/h3-13,18,24H,2,14-17,19H2,1H3;1H
PubChem CID	6602594
ChEMBL	CHEMBL1415721
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Potency	28183.8 nM	PubChem BioAssay data set	ChEMBL

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