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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Rattus norvegicus (Rat)
Gene	Htr2b
Synonym	stomach fundus serotonin receptor serotonin receptor 2B 5-HT-2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 5-HT2F 5-HT2B receptor 5-HT2B 5-HT-2F {ECO:0000303\|PubMed:1331748} Stomach fundus serotonin receptor {ECO:0000303\|PubMed:1505525} [ Show all ]
Disease	N/A for non-human GPCRs
Length	479
Amino acid sequence	MASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMVMLDGSHKDKILPNSTDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTKHGIRNGINPAMYQSPVRLRSSTIQSSSIILLNTFLTENDGDKVEDQVSYI
UniProt	P30994
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL323
IUPHAR	7
DrugBank	N/A

Ligand

Name	2,3-Dimethoxyamphetamine
Molecular formula	C11H17NO2
IUPAC name	1-(2,3-dimethoxyphenyl)propan-2-amine
Molecular weight	195.262
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	1.5
Synonyms	1-(2,3-Dimethoxyphenyl)-2-propanamine AKOS022488574 Dimethoxyamphetamine 15402-81-0 Benzeneethanamine,2,3-dimethoxy-.alpha.-methyl- AC1L3LPJ CTK6J4170 1-(2,3-Dimethoxyphenyl)-2-propanamine # BDBM50091080 SCHEMBL729393 (+/-)2-(2,3-Dimethoxy-phenyl)-1-methyl-ethylamine AKOS000152288 DHLWJXGSZDJWKK-UHFFFAOYSA-N 1-(2,3-dimethoxyphenyl)propan-2-amine Benzeneethanamine, 2,3-dimethoxy-alpha-methyl- CHEMBL280855 [ Show all ]
Inchi Key	DHLWJXGSZDJWKK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H17NO2/c1-8(12)7-9-5-4-6-10(13-2)11(9)14-3/h4-6,8H,7,12H2,1-3H3
PubChem CID	91255
ChEMBL	CHEMBL280855
IUPHAR	N/A
BindingDB	50091080
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	2884.03 nM	PMID7310818	BindingDB,ChEMBL

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