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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Free fatty acid receptor 1
Species	Homo sapiens (Human)
Gene	FFAR1
Synonym	FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40 FFA1 receptor
Disease	Type 2 diabetes Non-insulin dependent diabetes Diabetes
Length	300
Amino acid sequence	MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProt	O14842
Protein Data Bank	5tzy, 5tzr
GPCR-HGmod model	O14842
3D structure model	This structure is from PDB ID 5tzy.
BioLiP	BL0380462, BL0380463, BL0380464
Therapeutic Target Database	T25608
ChEMBL	CHEMBL4422
IUPHAR	225
DrugBank	BE0000688

Ligand

Name	CHEMBL3265141
Molecular formula	C33H39FO5
IUPAC name	(3S)-3-cyclopropyl-3-[3-[[3-[(1R)-1-ethoxy-2,2-dimethylpropyl]-4-(2-fluoro-5-methoxyphenyl)phenyl]methoxy]phenyl]propanoic acid
Molecular weight	534.668
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	7.5
Synonyms	BDBM50010918 SCHEMBL2505371
Inchi Key	AAXGNQYETKQKSK-UCGGBYDDSA-N
Inchi ID	InChI=1S/C33H39FO5/c1-6-38-32(33(2,3)4)29-16-21(10-14-26(29)28-18-24(37-5)13-15-30(28)34)20-39-25-9-7-8-23(17-25)27(19-31(35)36)22-11-12-22/h7-10,13-18,22,27,32H,6,11-12,19-20H2,1-5H3,(H,35,36)/t27-,32-/m0/s1
PubChem CID	57707214
ChEMBL	CHEMBL3265141
IUPHAR	N/A
BindingDB	50010918
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	114.0 nM	PMID24900845	BindingDB,ChEMBL
Emax	101.0 %	PMID24900845	ChEMBL

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