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GPCR

NameMetabotropic glutamate receptor 3
SpeciesRattus norvegicus (Rat)
GeneGrm3
SynonymmGluR3
mGlu3 receptor
GPRC1C
glutamate receptor
DiseaseN/A for non-human GPCRs
Length879
Amino acid sequenceMKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL
UniProtP31422
Protein Data Bank2e4u, 2e4v, 2e4w, 2e4x, 2e4y
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 2e4u.
BioLiPBL0086116,BL0086117, BL0086120,BL0086121, BL0086118,BL0086119, BL0086114,BL0086115, BL0086112,BL0086113
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3067
IUPHAR291
DrugBankN/A

Ligand

NameCHEMBL3288637
Molecular formulaC23H17N3O
IUPAC name4-methyl-2,8-diphenylpyrazolo[1,5-a]quinazolin-5-one
Molecular weight351.409
Hydrogen bond acceptor2
Hydrogen bond donor0
XlogP4.6
SynonymsBDBM50017597
Inchi KeyDGKIZEFUZLOZHA-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H17N3O/c1-25-22-15-20(17-10-6-3-7-11-17)24-26(22)21-14-18(12-13-19(21)23(25)27)16-8-4-2-5-9-16/h2-15H,1H3
PubChem CID90643955
ChEMBLCHEMBL3288637
IUPHARN/A
BindingDB50017597
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<10000.0 nMPMID24794112BindingDB,ChEMBL

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