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GPCR

NameMetabotropic glutamate receptor 2
SpeciesHomo sapiens (Human)
GeneGRM2
SynonymmGluR2
mGlu2 receptor
metabotropic glutamate receptor 2
GPRC1B
glutamate receptor
DiseaseCentral nervous system disease
Anxiety disorder
Bipolar disorder
Major depressive disorder
Mood disorder
[ Show all ]
Length872
Amino acid sequenceMGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
UniProtQ14416
Protein Data Bank5cnj, 5kzn, 5kzq, 5cni, 4xas, 4xaq
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 5cnj.
BioLiPBL0365442, BL0324559,BL0324560, BL0324557,BL0324558, BL0306697,BL0306698, BL0306695,BL0306696, BL0365443
Therapeutic Target DatabaseT62820
ChEMBLCHEMBL5137
IUPHAR290
DrugBankN/A

Ligand

NameCHEMBL1629865
Molecular formulaC22H16F3N3O
IUPAC name4-[3-(2-methylpyridin-4-yl)phenyl]-8-(trifluoromethyl)-1,3-dihydro-1,5-benzodiazepin-2-one
Molecular weight395.385
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP4.3
SynonymsSCHEMBL5563741
4-(3-(2-methylpyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
BDBM50333000
DFWDFOZNVALGES-UHFFFAOYSA-N
4-[3-(2-Methyl-pyridin-4-yl)-phenyl]-8-trifluoromethyl-1,3-dihydro benzo[b][1,4]diazepin-2-one
Inchi KeyDFWDFOZNVALGES-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H16F3N3O/c1-13-9-15(7-8-26-13)14-3-2-4-16(10-14)19-12-21(29)28-20-11-17(22(23,24)25)5-6-18(20)27-19/h2-11H,12H2,1H3,(H,28,29)
PubChem CID11211597
ChEMBLCHEMBL1629865
IUPHARN/A
BindingDB50333000
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5018.0 nMPMID20971004BindingDB
IC5025.0 nMPMID20971004BindingDB,ChEMBL
IC5036.0 nMPMID20971004BindingDB

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