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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Mus musculus (Mouse)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 Serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDDSRLYPNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLSSFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPTLAYKSSQLQVGQKKNSQEDAEPTANDCSMVTLGNQHSEEMCTDNIETVNEKVSCV
UniProt	P35363
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5377
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Piribedil mesylate
Molecular formula	C17H22N4O5S
IUPAC name	2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine;methanesulfonic acid
Molecular weight	394.446
Hydrogen bond acceptor	9
Hydrogen bond donor	1
XlogP	None
Synonyms	Piribedil methanesulfonate SMR000058709 1U37NGM6KK AC1L5518 ET 495 methanesulfonate Piribedil monomethylsulfonate 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine; methanesulfonic acid C16H18N4O2.CH4O3S I14-7668 Pyrimidine, 2-(4-piperonyl-1-piperazinyl)-, methanesulfonate 52293-23-9 DTXSID30200314 Opera_ID_1848 Piribedil methylsulfonate UNII-1U37NGM6KK 2-(4-(1,3-Benzodioxol-5-ylmethyl)piperazinyl)pyrimidinium methanesulphonate ACM52293239 HMS2230N20 Pyrimidine, 2-(4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)-, monomethanesulfonate 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazinyl]pyrimidinium methanesulfonate LS-135518 SCHEMBL1652330 1-(3,4-METHYLENEDIOXYBENZYL)-4-(2-PYRIMIDYL)-PIPERAZINE MONO(METHANESULFONATE) SALT A823101 EINECS 257-818-8 Piribedil monomethanesulfonate 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine; methanesulfonic acid AKOS015918393 HMS3373M21 Pyrimidine, 2-(4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)-, monomethanesulfonate (9CI) 3605-01-4 (Parent) CHEMBL1468572 MLS000028838 [ Show all ]
Inchi Key	DEZKFCIOSKCCHK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H18N4O2.CH4O3S/c1-4-17-16(18-5-1)20-8-6-19(7-9-20)11-13-2-3-14-15(10-13)22-12-21-14;1-5(2,3)4/h1-5,10H,6-9,11-12H2;1H3,(H,2,3,4)
PubChem CID	198284
ChEMBL	CHEMBL1468572
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
EC50	9.86 nM	PubChem BioAssay data set	ChEMBL

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