You can:
Name | Somatostatin receptor type 2 |
---|---|
Species | Homo sapiens (Human) |
Gene | SSTR2 |
Synonym | somatotropin release-inhibiting factor receptor SRIF-1 SS-2-R SS2-R SS2R [ Show all ] |
Disease | Acromegaly Lung cancer Neuroendocrine cancer |
Length | 369 |
Amino acid sequence | MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI |
UniProt | P30874 |
Protein Data Bank | N/A |
GPCR-HGmod model | P30874 |
3D structure model | This predicted structure model is from GPCR-EXP P30874. |
BioLiP | N/A |
Therapeutic Target Database | T53024 |
ChEMBL | CHEMBL1804 |
IUPHAR | 356 |
DrugBank | BE0003528 |
Name | Octreotide |
---|---|
Molecular formula | C49H66N10O10S2 |
IUPAC name | (4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide |
Molecular weight | 1019.25 |
Hydrogen bond acceptor | 14 |
Hydrogen bond donor | 13 |
XlogP | 1.0 |
Synonyms | RWM8CCW8GP 10-(4-Amino-butyl)-19-(2-amino-3-phenyl-propionylamino)-16-benzyl-7-(1-hydroxy-ethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carboxylic acid (2-hydroxy-1- 79517-01-4b CHEMBL1680 KS-000011F3 [ Show all ] |
Inchi Key | DEQANNDTNATYII-OULOTJBUSA-N |
Inchi ID | InChI=1S/C49H66N10O10S2/c1-28(61)39(25-60)56-48(68)41-27-71-70-26-40(57-43(63)34(51)21-30-13-5-3-6-14-30)47(67)54-37(22-31-15-7-4-8-16-31)45(65)55-38(23-32-24-52-35-18-10-9-17-33(32)35)46(66)53-36(19-11-12-20-50)44(64)59-42(29(2)62)49(69)58-41/h3-10,13-18,24,28-29,34,36-42,52,60-62H,11-12,19-23,25-27,50-51H2,1-2H3,(H,53,66)(H,54,67)(H,55,65)(H,56,68)(H,57,63)(H,58,69)(H,59,64)/t28-,29-,34-,36+,37+,38-,39-,40+,41+,42+/m1/s1 |
PubChem CID | 448601 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 50272772 |
DrugBank | DB00104 |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
N/A | N/A | DrugBank | |
IC50 | 0.02 nM | PMID16220980 | BindingDB |
Ki | 0.3 nM | PMID9822540 | BindingDB |
Ki | 0.57 nM | PMID16220980 | BindingDB |
Ki | 2.1 nM | PMID18656351 | BindingDB |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417