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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Muscarinic acetylcholine receptor M2
Species	Homo sapiens (Human)
Gene	CHRM2
Synonym	cholinergic receptor AChR M2 M2 muscarinic acetylcholine receptor M2 receptor Chrm-2 cholinergic receptor, muscarinic 2, cardiac cholinergic receptor, muscarinic 2 [ Show all ]
Disease	Urinary incontinence Heart failure Nausea; Addiction Parkinson's disease Peptic ulcer Stabilize muscle contractions Unspecified Cardiovascular disorder Asthma Alzheimer disease [ Show all ]
Length	466
Amino acid sequence	MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProt	P08172
Protein Data Bank	5zkc, 4mqs, 4mqt, 5yc8, 5zk3, 5zkb, 5zk8
GPCR-HGmod model	P08172
3D structure model	This structure is from PDB ID 5zkc.
BioLiP	BL0433341, BL0433216, BL0263147, BL0263146, BL0263145, BL0433339, BL0433340, BL0433338
Therapeutic Target Database	T46185
ChEMBL	CHEMBL211
IUPHAR	14
DrugBank	BE0000560

Ligand

Name	1-(4-Bromobenzyl)indole-2,3-dione
Molecular formula	C15H10BrNO2
IUPAC name	1-[(4-bromophenyl)methyl]indole-2,3-dione
Molecular weight	316.154
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	2.8
Synonyms	1-[(4-bromophenyl)methyl]indole-2,3-dione AH-034/08903023 EN300-70451 SR-01000395993 ZINC2454837 CCG-198352 K015-0020 STK215777 1-(4-bromobenzyl)-1H-indole-2,3-dione 1-[(4-bromophenyl)methyl]-2,3-dihydro-1H-indole-2,3-dione AC1MHO09 cid_3008304 NE20417 VU0119498 1-[(4-bromophenyl)methyl]indoline-2,3-dione AKOS000245456 EU-0067620 SR-01000395993-1 MCULE-6184534031 VU 0119498 1-[(4-bromophenyl)methyl]benzo[d]azolidine-2,3-dione AC1Q24VD D0JV2S SCHEMBL5430888 VU0119498-2 1H-Indole-2,3-dione, 1-[(4-bromophenyl)methyl]- BDBM50258439 GTPL7632 ST50892639 79183-37-2 CHEMBL523685 MolPort-002-341-984 VU-0119498 1-(4-bromobenzyl)indoline-2,3-dione [ Show all ]
Inchi Key	DELLOEULSHGYCG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
PubChem CID	3008304
ChEMBL	CHEMBL523685
IUPHAR	7632
BindingDB	50258439
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<30000.0 nM	PMID20801651	BindingDB,ChEMBL

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