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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M4
Species	Rattus norvegicus (Rat)
Gene	Chrm4
Synonym	cholinergic receptor cholinergic receptor, muscarinic 4 Chrm-4 HM3 M4 receptor
Disease	N/A for non-human GPCRs
Length	478
Amino acid sequence	MXNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
UniProt	P08485
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL317
IUPHAR	16
DrugBank	N/A

Ligand

Name	1-(4-Bromobenzyl)indole-2,3-dione
Molecular formula	C15H10BrNO2
IUPAC name	1-[(4-bromophenyl)methyl]indole-2,3-dione
Molecular weight	316.154
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	2.8
Synonyms	1-[(4-bromophenyl)methyl]indole-2,3-dione AH-034/08903023 EN300-70451 SR-01000395993 ZINC2454837 1-(4-bromobenzyl)-1H-indole-2,3-dione CCG-198352 K015-0020 STK215777 1-[(4-bromophenyl)methyl]-2,3-dihydro-1H-indole-2,3-dione AC1MHO09 cid_3008304 NE20417 VU0119498 1-[(4-bromophenyl)methyl]indoline-2,3-dione AKOS000245456 EU-0067620 SR-01000395993-1 MCULE-6184534031 VU 0119498 1-[(4-bromophenyl)methyl]benzo[d]azolidine-2,3-dione AC1Q24VD D0JV2S SCHEMBL5430888 VU0119498-2 1H-Indole-2,3-dione, 1-[(4-bromophenyl)methyl]- BDBM50258439 GTPL7632 ST50892639 1-(4-bromobenzyl)indoline-2,3-dione 79183-37-2 CHEMBL523685 MolPort-002-341-984 VU-0119498 [ Show all ]
Inchi Key	DELLOEULSHGYCG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
PubChem CID	3008304
ChEMBL	CHEMBL523685
IUPHAR	7632
BindingDB	50258439
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<30000.0 nM	PMID20004578	BindingDB,ChEMBL

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