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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H3 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH3
Synonym	H3R HH3R
Disease	N/A for non-human GPCRs
Length	445
Amino acid sequence	MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGAREAGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHSSLEHCWK
UniProt	Q9JI35
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5076
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Iodoproxyfan
Molecular formula	C13H15IN2O
IUPAC name	5-[3-[(4-iodophenyl)methoxy]propyl]-1H-imidazole
Molecular weight	342.18
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	2.7
Synonyms	152028-96-1 BDBM22916 PDSP1_000544 3-(1H-Imidazol-4-yl)propyl-(4-iodophenyl)methyl ether D08BSG ZINC5117186 (125I)Iodoproxyfan 5-{3-[(4-iodophenyl)methoxy]propyl}-1H-imidazole 1H-Imidazole, 4-(3-((4-iodophenyl)methoxy)propyl)- PDSP2_000542 4-[3-[(4-iodophenyl)methoxy]propyl]-3H-imidazole DTXSID30164942 AC1L31V0 L010934 CHEMBL19010 SCHEMBL3089477 5-[3-[(4-iodophenyl)methoxy]propyl]-1H-imidazole GTPL1253 [ Show all ]
Inchi Key	DCQNAFOCXVCDLB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H15IN2O/c14-12-5-3-11(4-6-12)9-17-7-1-2-13-8-15-10-16-13/h3-6,8,10H,1-2,7,9H2,(H,15,16)
PubChem CID	132937
ChEMBL	CHEMBL19010
IUPHAR	1253
BindingDB	22916
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	5.01 nM	PMID11356102	BindingDB
Kd	5.012 nM	PMID11356102	ChEMBL

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