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GPCR

NameMetabotropic glutamate receptor 4
SpeciesRattus norvegicus (Rat)
GeneGrm4
Synonymglutamate receptor
GPRC1D
mGlu4 receptor
mGluR4
DiseaseN/A for non-human GPCRs
Length912
Amino acid sequenceMSGKGGWAWWWARLPLCLLLSLYAPWVPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTLASEGSYGESGVEAFIQKSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETSNARGIIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHIKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNGSAEYKVIGSWTDHLHLRIERMQWPGSGQQLPRSICSLPCQPGERKKTVKGMACCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTSCQPIPIVKLEWDSPWAVLPLFLAVVGIAATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFILISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLETPALATKQTYVTYTNHAI
UniProtP31423
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2787
IUPHAR292
DrugBankN/A

Ligand

NameUS9212196, Derivative 11
Molecular formulaC14H18NO7P
IUPAC name(2R)-2-amino-4-[[[4-[(E)-2-carboxyethenyl]phenyl]-hydroxymethyl]-hydroxyphosphoryl]butanoic acid
Molecular weight343.272
Hydrogen bond acceptor8
Hydrogen bond donor5
XlogP-3.5
SynonymsBDBM196915
Inchi KeyQKKOTCXCHRJFNS-WQMQZYANSA-N
Inchi IDInChI=1S/C14H18NO7P/c15-11(13(18)19)7-8-23(21,22)14(20)10-4-1-9(2-5-10)3-6-12(16)17/h1-6,11,14,20H,7-8,15H2,(H,16,17)(H,18,19)(H,21,22)/b6-3+/t11-,14?/m1/s1
PubChem CID122197943
ChEMBLN/A
IUPHARN/A
BindingDB196915
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50480.0 nMN/ABindingDB

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