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Name | Metabotropic glutamate receptor 4 |
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Species | Rattus norvegicus (Rat) |
Gene | Grm4 |
Synonym | glutamate receptor GPRC1D mGlu4 receptor mGluR4 |
Disease | N/A for non-human GPCRs |
Length | 912 |
Amino acid sequence | MSGKGGWAWWWARLPLCLLLSLYAPWVPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTLASEGSYGESGVEAFIQKSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETSNARGIIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHIKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNGSAEYKVIGSWTDHLHLRIERMQWPGSGQQLPRSICSLPCQPGERKKTVKGMACCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTSCQPIPIVKLEWDSPWAVLPLFLAVVGIAATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFILISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLETPALATKQTYVTYTNHAI |
UniProt | P31423 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2787 |
IUPHAR | 292 |
DrugBank | N/A |
Name | US9212196, Derivative 18 |
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Molecular formula | C15H20NO11P |
IUPAC name | (2R)-2-amino-4-[[[3,4-bis(carboxymethoxy)phenyl]-hydroxymethyl]-hydroxyphosphoryl]butanoic acid |
Molecular weight | 421.295 |
Hydrogen bond acceptor | 12 |
Hydrogen bond donor | 6 |
XlogP | -4.3 |
Synonyms | BDBM196922 |
Inchi Key | LIXSYEXTLWDJIL-WXMRUQJCSA-N |
Inchi ID | InChI=1S/C15H20NO11P/c16-9(14(21)22)3-4-28(24,25)15(23)8-1-2-10(26-6-12(17)18)11(5-8)27-7-13(19)20/h1-2,5,9,15,23H,3-4,6-7,16H2,(H,17,18)(H,19,20)(H,21,22)(H,24,25)/t9-,15?/m1/s1 |
PubChem CID | 122197948 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 196922 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 2500.0 nM | N/A | BindingDB |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417