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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Metabotropic glutamate receptor 6
Species	Rattus norvegicus (Rat)
Gene	Grm6
Synonym	nob3 nob2 nerg1 mGluR6 mGlu6 receptor Gprc1f glutamate receptor nob4 [ Show all ]
Disease	N/A for non-human GPCRs
Length	871
Amino acid sequence	MGRLPVLLLWLAWWLSQAGIACGAGSVRLAGGLTLGGLFPVHARGAAGRACGALKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEASVRCPGGVPPLRSAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFHKVIRRLMETPNARGIIIFANEDDIRRVLEATRQANLTGHFLWVGSDSWGSKISPILNLEEEAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGGQSDDSTRKCTGEERIGQDSAYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRTLLHYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAEALRLDMEVLRWSGDPHEVPPSQCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLTWSSPWAALPLLLAVLGIMATTTIMATFMRHNDTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPCAAICAARRLLLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFGLTSLQVVGVIAWLGAQPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKKTSTMAAPPQNENAEDAK
UniProt	P35349
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3842
IUPHAR	294
DrugBank	N/A

Ligand

Name	CHEMBL539760
Molecular formula	C13H15N3O6
IUPAC name	(2R,4R)-4-amino-1-[(3-nitrophenyl)methyl]pyrrolidine-2,4-dicarboxylic acid
Molecular weight	309.278
Hydrogen bond acceptor	8
Hydrogen bond donor	3
XlogP	-4.7
Synonyms	(2R)-1-(3-Nitrobenzyl)-4-aminopyrrolidine-2beta,4alpha-dicarboxylic acid BDBM50102125 (2R,4R)-4-amino-1-(3-nitrobenzyl)pyrrolidine-2,4-dicarboxylic acid dihydrochloride CHEMBL1189910
Inchi Key	JKNQVGYOGNQKRM-ZWNOBZJWSA-N
Inchi ID	InChI=1S/C13H15N3O6/c14-13(12(19)20)5-10(11(17)18)15(7-13)6-8-2-1-3-9(4-8)16(21)22/h1-4,10H,5-7,14H2,(H,17,18)(H,19,20)/t10-,13-/m1/s1
PubChem CID	10385210
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50102125
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	100000.0 nM	PMID11459661	BindingDB

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