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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	MLS001125585
Molecular formula	C16H11BrN2O3
IUPAC name	5-bromo-N-[(E)-(2-hydroxynaphthalen-1-yl)methylideneamino]furan-2-carboxamide
Molecular weight	359.179
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	4.1
Synonyms	ARONIS000553 SMR000658956 5-bromo-N'-[(2-oxonaphthalen-1-ylidene)methyl]furan-2-carbohydrazide 5-bromo-N'-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]furan-2-carbohydrazide STK018914 AC1O9HTF 5-bromo-N''-[(Z)-(2-oxo-1-naphthalenylidene)methyl]-2-furancarbohydrazide BB0277923 SR-01000213133 5-bromo-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]furan-2-carbohydrazide AC1NURTI CHEMBL1983939 5-bromanyl-N''-[(Z)-(2-oxidanylidenenaphthalen-1-ylidene)methyl]furan-2-carbohydrazide AKOS000489967 MolPort-001-028-438 5-bromo-N''-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]furan-2-carbohydrazide BDBM77590 SR-01000213133-1 5-bromo-N'-[(E)-(2-oxonaphthalen-1-ylidene)methyl]furan-2-carbohydrazide AC1O6RMK cid_6505442 5-bromo-N''-[(Z)-(2-keto-1-naphthylidene)methyl]-2-furohydrazide [ Show all ]
Inchi Key	HLEUDUNWWHNOLP-GIJQJNRQSA-N
Inchi ID	InChI=1S/C16H11BrN2O3/c17-15-8-7-14(22-15)16(21)19-18-9-12-11-4-2-1-3-10(11)5-6-13(12)20/h1-9,20H,(H,19,21)/b18-9+
PubChem CID	135541766
ChEMBL	CHEMBL1983939
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	1778.3 nM	PubChem BioAssay data set	ChEMBL

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