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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 Niacin receptor 1 G-protein coupled receptor 109A G-protein coupled receptor HM74A HCA2 receptor [ Show all ]
Disease	Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis Arteriosclerosis Acute ischemic stroke [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	2-(3-(3-(4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl)propanamido)benzoic acid
Molecular formula	C18H15N3O5
IUPAC name	2-[3-[3-(4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl]propanoylamino]benzoic acid
Molecular weight	353.334
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	2.6
Synonyms	AKOS022177276 960605-08-7 BDBM23527 CHEMBL391813 2-{3-[3-(4-hydroxyphenyl)-1,2,4-oxadiazol-5-yl]propanamido}benzoic acid AJ-83596 Biaryl Anthranilide Analogue, 2i SCHEMBL12671396 [ Show all ]
Inchi Key	GRGWIIOJSGTREV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H15N3O5/c22-12-7-5-11(6-8-12)17-20-16(26-21-17)10-9-15(23)19-14-4-2-1-3-13(14)18(24)25/h1-8,22H,9-10H2,(H,19,23)(H,24,25)
PubChem CID	135800177
ChEMBL	CHEMBL391813
IUPHAR	N/A
BindingDB	23527
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	120.0 nM	PMID17994679, PMID21185185	BindingDB,ChEMBL
Fold change	40.0 -	PMID17994679	ChEMBL
IC50	10.0 nM	PMID17994679, PMID21185185	BindingDB,ChEMBL
Ratio IC50	40.0 -	PMID21185185	ChEMBL

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