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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin E2 receptor EP2 subtype
Species	Homo sapiens (Human)
Gene	PTGER2
Synonym	PGE receptor EP2 subtype PGE2 receptor EP2 subtype prostaglandin E receptor 2 (subtype EP2), 53kDa Prostanoid EP2 receptor Ptger-ep2 EP2 receptor [ Show all ]
Disease	Osteoporosis Pulmonary arterial hypertension Miscarriage Medical abortion Immune disorder Glaucoma Solid tumours Endometriosis Diabetic foot ulcer Cancer [ Show all ]
Length	358
Amino acid sequence	MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
UniProt	P43116
Protein Data Bank	N/A
GPCR-HGmod model	P43116
3D structure model	This predicted structure model is from GPCR-EXP P43116.
BioLiP	N/A
Therapeutic Target Database	T38529
ChEMBL	CHEMBL1881
IUPHAR	341
DrugBank	BE0000368

Ligand

Name	SCHEMBL18357252
Molecular formula	C30H29ClFNO4
IUPAC name	4-[3-[(2R)-2-[(E)-3-[3-(4-chloro-2-methylphenyl)-5-fluorophenyl]-3-hydroxyprop-1-enyl]-5-oxopyrrolidin-1-yl]propyl]benzoic acid
Molecular weight	522.013
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	5.7
Synonyms	US9540357, example 34 BDBM202472 US9540357, example 35
Inchi Key	BBTVQJNBBOHHAH-BUNSPHNPSA-N
Inchi ID	InChI=1S/C30H29ClFNO4/c1-19-15-24(31)8-11-27(19)22-16-23(18-25(32)17-22)28(34)12-9-26-10-13-29(35)33(26)14-2-3-20-4-6-21(7-5-20)30(36)37/h4-9,11-12,15-18,26,28,34H,2-3,10,13-14H2,1H3,(H,36,37)/b12-9+/t26-,28?/m0/s1
PubChem CID	124170712
ChEMBL	N/A
IUPHAR	N/A
BindingDB	202472
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	N/A	BindingDB

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