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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	MLS000516332
Molecular formula	C13H14N4O4S2
IUPAC name	N-[6-amino-1-(2-methoxyethyl)-2,4-dioxopyrimidine-5-carbothioyl]thiophene-2-carboxamide
Molecular weight	354.399
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	0.7
Synonyms	cid_2422324 N-[6-azanyl-1-(2-methoxyethyl)-2,4-bis(oxidanylidene)pyrimidin-5-yl]carbothioylthiophene-2-carboxamide Z55673193 AC1M7OHL N-[6-amino-1-(2-methoxyethyl)-2,4-dioxopyrimidine-5-carbothioyl]thiophene-2-carboxamide HMS2765M06 N-[[6-amino-1-(2-methoxyethyl)-2,4-dioxo-5-pyrimidinyl]-sulfanylidenemethyl]-2-thiophenecarboxamide MolPort-004-260-001 ZINC3306605 AKOS034446457 CHEMBL1609964 N-[6-amino-2,4-diketo-1-(2-methoxyethyl)pyrimidine-5-carbothioyl]thiophene-2-carboxamide MCULE-7448540707 SMR000372893 732271-53-3 BDBM56784 N-[6-amino-1-(2-methoxyethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbothioyl]thiophene-2-carboxamide [ Show all ]
Inchi Key	AHIICCMXLOFYNH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H14N4O4S2/c1-21-5-4-17-9(14)8(11(19)16-13(17)20)12(22)15-10(18)7-3-2-6-23-7/h2-3,6H,4-5,14H2,1H3,(H,15,18,22)(H,16,19,20)
PubChem CID	2422324
ChEMBL	CHEMBL1609964
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	31622.8 nM	PubChem BioAssay data set	ChEMBL

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