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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Rattus norvegicus (Rat)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
UniProt	P14842
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL322
IUPHAR	6
DrugBank	N/A

Ligand

Name	339071-18-0
Molecular formula	C11H14ClN3O2
IUPAC name	N'-(3-chloro-4-morpholin-4-ylphenyl)-N-hydroxymethanimidamide
Molecular weight	255.702
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.3
Synonyms	DS-16349 N-(3-Chloro-4-morpholinophenyl)-N-hydroxyformimidamide AKOS022180267 Methanimidamide, N-[3-chloro-4-(4-morpholinyl)phenyl]-N'-hydroxy- ZINC6746071 (E)-N-(3-chloro-4-Morpholinophenyl)-N'-hydroxyforMiMidaMide CTK1B8099 N'-(3-Chloro-4-morpholinophenyl)-N-hydroxyformamidine AJ-56824 DTXSID00431234 SCHEMBL3983851 BDBM86694 MolPort-035-681-438 D09LKR N-(3-Chloro-4-morpholinophenyl)-N'-hydroxyformimidamide AK-59782 HY-15603 TS-011 CS-0007825 MolPort-044-723-707 [ Show all ]
Inchi Key	ZTXADXBIGLLOFX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H14ClN3O2/c12-10-7-9(13-8-14-16)1-2-11(10)15-3-5-17-6-4-15/h1-2,7-8,16H,3-6H2,(H,13,14)
PubChem CID	9816527
ChEMBL	N/A
IUPHAR	N/A
BindingDB	86694
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID15831442	BindingDB

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