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GPCR

Name	Alpha-1A adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra1a
Synonym	alpha1c alpha1A-adrenoceptor alpha1a Alpha-1C adrenergic receptor Alpha-1A adrenoreceptor Alpha-1A adrenoceptor alpha-1A adrenergic receptor ADRA1C alpha 1C-adrenergic receptor alpha 1A-adrenoreceptor alpha 1A-adrenoceptor adrenergic receptor, alpha 1a adrenergic receptor alpha 1c adrenergic alpha 1c receptor ADRA1L1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
UniProt	P43140
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL319
IUPHAR	22
DrugBank	N/A

Ligand

Name	dopamine
Molecular formula	C8H11NO2
IUPAC name	4-(2-aminoethyl)benzene-1,2-diol
Molecular weight	153.181
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	-1.0
Synonyms	1,2-Benzenediol, 4-(2-aminoethyl)- SBB004044 4-(2-Aminoethyl)-1 DSSTox_RID_76584 13510-EP2272847A1 Spectrum4_000525 4-(2-Aminoethyl)pyrocatechol IDI1_000780 13510-EP2284170A1 T7923 a-(3,4-Dihydroxyphenyl)-b-aminoethane KBio2_002388 13510-EP2295437A1 ZINC33882 AKOS003790978 KBio3_001152 13510-EP2298775A1 Biomol-NT_000001 KBioSS_002491 13510-EP2305648A1 CCG-204675 m-Hydroxytyramine- 13510-EP2308828A2 D07870 NCGC00015519-04 13510-EP2311818A1 NCGC00096050-02 153C5321-5FEE-4B0B-8925-F388F0EEEBD1 NSC173182 3,4-dihydroxyphenethylamine 3-Hydroxtyramine 1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium Sinemet 4-(2-Aminoethyl)-1,2-bezenediol FT-0698513 13510-EP2280010A2 SR-01000075366 4CH-018780 Intropin [hydrochloride] 13510-EP2287161A1 TX-016804 AB00053463_14 KBio2_004956 13510-EP2298313A1 ANW-54385 KBioGR_001129 13510-EP2301933A1 BP-23276 L000232 13510-EP2305656A1 CHEMBL59 MFCD00130258 13510-EP2308875A1 DB00988 NCGC00015519-08 13510-EP2311835A1 Dopamine [INN:BAN] NCGC00096050-05 2-(3,4-Dihydroxyphenyl)-1-ethanamine (3H)-Dopamine Pyrocatechol, 4-(2-aminoethyl)- .beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride 3-Hydroxytyramine HCl salt DSSTox_CID_2420 13510-EP2272537A2 Spectrum2_001023 4-(2-aminoethyl)benzene-1,2-diol;hydrochloride Hydroxytyramin 13510-EP2281819A1 ST2405321 62-31-7 (HYDROCHLORIDE) KBio1_000780 13510-EP2287166A2 VTD58H1Z2X AC1Q54AY KBio2_007524 13510-EP2298758A1 BDBM55121 KBioSS_001492 13510-EP2305640A2 C03758 Lopac0_000586 13510-EP2305675A1 cMAP_000065 NCGC00015519-02 13510-EP2311802A1 Dopamina NCGC00015519-11 13510-EP2316836A1 NSC-173182 2-(4-Hydroxy-5-oxylatophenyl)-1-ethanaminium 1,2-Benzenediol, 4-(2-aminoethyl)- (9CI) SBI-0050568.P004 4-(2-Aminoethyl)-1,2-benzenediol DTXSID6022420 13510-EP2275420A1 Spectrum5_000945 4-(2-aminoethyl)pyrocatechol;hydrochloride intropin 13510-EP2284171A1 Tox21_110167 AB00053463-12 KBio2_002484 13510-EP2295439A1 alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane KBio3_002867 13510-EP2298776A1 bmse000909 KW-3-060 13510-EP2305650A1 CHEBI:18243 MCULE-7558764100 13510-EP2308867A2 D0T7OW NCGC00015519-05 13510-EP2311827A1 Dopamine (INN) NCGC00096050-03 2-(3, 4-Dihydroxyphenyl)ethylamine Oprea1_088821 3,4-Dihydroxyphenylethylamine 3-Hydroxytyramine 13510-EP2269989A1 SPBio_001205 4-(2-aminoethyl)-pyrocatechol GTPL940 13510-EP2281559A1 SR-01000075366-7 51-61-6 IP 498 13510-EP2287162A1 UNII-VTD58H1Z2X AC1L19S5 KBio2_005052 13510-EP2298731A1 ASL 279 KBioGR_002388 13510-EP2305260A1 BPBio1_001123 LDP 13510-EP2305659A1 cid_65340 MolPort-001-641-000 13510-EP2311494A1 DivK1c_000780 NCGC00015519-09 13510-EP2314571A2 Dopaminum NINDS_000780 2-(3,4-dihydroxyphenyl)ethylamine Pyrocatechol, 4-(2-aminoethyl)- (8CI) 1, 4-(2-aminoethyl)- Revimine 4-(2-Amino-ethyl)-benzene-1,2-diol DSSTox_GSID_22420 13510-EP2272825A2 Spectrum3_000406 4-(2-Aminoethyl)catechol hydroxytyramine 13510-EP2284169A1 STK301601 KBio2_001492 13510-EP2292620A2 VYFYYTLLBUKUHU-UHFFFAOYSA-N AJ-08579 KBio2_007620 13510-EP2298759A1 BIDD:ER0506 KBioSS_002393 13510-EP2305644A1 CAS-51-61-6 LS-159 13510-EP2305689A1 CTK4E3164 NCGC00015519-03 13510-EP2311803A1 Dopamina [INN-Spanish] NCGC00096050-01 13510-EP2371814A1 NSC169105 2-benzenediol 3- HYDROXYTYRAMINE 1,2-Benzenediol, 4-(2-aminoethyl)-(9CI) SCHEMBL8505 4-(2-Aminoethyl)-1,2-benzenediol # EINECS 200-110-0 13510-EP2277882A1 Spectrum_001012 4-(2-azanylethyl)benzene-1,2-diol;hydrochloride Intropin (Salt/Mix) 13510-EP2286811A1 Tox21_110167_1 AB00053463_13 KBio2_004060 13510-EP2298312A1 AN-41611 KBio3_002962 13510-EP2301540A1 bmse000933 L-DOPAMINE 13510-EP2305652A2 Medopa (TN) 13510-EP2308870A2 NCGC00015519-07 13510-EP2311828A1 Dopamine (USAN)(hydrochloride) NCGC00096050-04 2-(3,4-dihydroxyphenyl) ethylamine Oxytyramine Pyrocatechol, 4-(2-aminoethyl)-(8CI) 3-Hydroxytyramine Hydrobromide Dophamine 13510-EP2270011A1 SPECTRUM1505155 4-(2-Aminoethyl)benzene-1,2-diol HSDB 3068 13510-EP2281815A1 ST048774 KB-237403 13510-EP2287165A2 UPCMLD0ENAT5885989:001 AC1Q54AX KBio2_006628 13510-EP2298734A2 BBL013043 KBioGR_002484 13510-EP2305633A1 BSPBio_001932 Lopac-H-8502 13510-EP2305664A1 cMAP_000036 NCGC00015519-01 13510-EP2311801A1 Dopamin NCGC00015519-10 13510-EP2316470A2 Dopaminum [INN-Latin] NSC 173182 2-(3,4-dihydroxyphenyl)ethylamine3,4-dihydroxyphenethylamine3-hydroxytyramine; DA; Intropin; Revivan; Oxytyramine .alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane [ Show all ]
Inchi Key	VYFYYTLLBUKUHU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
PubChem CID	681
ChEMBL	CHEMBL59
IUPHAR	940
BindingDB	55121
DrugBank	DB00988
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	250.0 nM	PMID17827	BindingDB
Ki	44000.0 nM	PMID17827	BindingDB

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