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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Somatostatin receptor type 2
Species	Homo sapiens (Human)
Gene	SSTR2
Synonym	somatotropin release-inhibiting factor receptor SRIF-1 SS-2-R SS2-R SS2R SST2 receptor [ Show all ]
Disease	Acromegaly Lung cancer Neuroendocrine cancer
Length	369
Amino acid sequence	MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
UniProt	P30874
Protein Data Bank	N/A
GPCR-HGmod model	P30874
3D structure model	This predicted structure model is from GPCR-EXP P30874.
BioLiP	N/A
Therapeutic Target Database	T53024
ChEMBL	CHEMBL1804
IUPHAR	356
DrugBank	BE0003528

Ligand

Name	cycloantagonist SA
Molecular formula	C42H55N7O5
IUPAC name	(3S,6S,9R,12S)-6-(4-aminobutyl)-12-benzyl-9-(1H-indol-3-ylmethyl)-3-[(1R)-1-phenoxyethyl]-1,4,7,10,13-pentazacyclononadecane-2,5,8,11-tetrone
Molecular weight	737.946
Hydrogen bond acceptor	7
Hydrogen bond donor	7
XlogP	4.8
Synonyms	c[Aha-Phe-D-Trp-Lys-Thr(Bzl)] BDBM82471
Inchi Key	UYLQYUAFNNCEIJ-GGMHJNBLSA-N
Inchi ID	InChI=1S/C42H55N7O5/c1-29(54-32-18-8-5-9-19-32)38-42(53)45-25-15-3-2-14-24-44-36(26-30-16-6-4-7-17-30)40(51)48-37(27-31-28-46-34-21-11-10-20-33(31)34)41(52)47-35(39(50)49-38)22-12-13-23-43/h4-11,16-21,28-29,35-38,44,46H,2-3,12-15,22-27,43H2,1H3,(H,45,53)(H,47,52)(H,48,51)(H,49,50)/t29-,35+,36+,37-,38+/m1/s1
PubChem CID	57339675
ChEMBL	N/A
IUPHAR	N/A
BindingDB	82471
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1258.92 nM	PMID9652348	BindingDB
Ki	1584.89 nM	PMID10598788, PMID9652348	BindingDB
Ki	1698.24 nM	PMID10598788, PMID9652348	BindingDB
Ki	1819.7 nM	PMID10598788	BindingDB
Ki	1819.7 nM	PMID9650799	BindingDB
Ki	2511.88 nM	PMID8769372	BindingDB
Ki	3715.35 nM	PMID9652348	BindingDB
Ki	3981.07 nM	PMID9652348, PMID10598788, PMID9650799	BindingDB

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