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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Homo sapiens (Human)
Gene	HTR7
Synonym	5-HT-7 Serotonin receptor 7 5-HT-X 5-HT1Y 5-HT7 GPRFO 5-HT7 receptor 5-HTx 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled [ Show all ]
Disease	Sleep disorders Schizophrenia Major depressive disorder
Length	479
Amino acid sequence	MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
UniProt	P34969
Protein Data Bank	N/A
GPCR-HGmod model	P34969
3D structure model	This predicted structure model is from GPCR-EXP P34969.
BioLiP	N/A
Therapeutic Target Database	T79062
ChEMBL	CHEMBL3155
IUPHAR	12
DrugBank	BE0000650, BE0004862

Ligand

Name	(2s)-2-amino-4-sulfinobutanoic acid
Molecular formula	C4H9NO4S
IUPAC name	(2S)-2-amino-4-sulfinobutanoic acid
Molecular weight	167.179
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	-3.8
Synonyms	L-Homocysteinesulphinic Acid ZINC25720432 Butanoic acid, 2-amino-4-sulfino-, (2S)- PDSP1_001272 CTK4F8661 L-homocysteine sulfinic acid PDSP2_001260 AKOS030568392 NCGC00163274-01 Butanoic acid,2-amino-4-sulfino-, (2S)- PDSP1_001276 AC1L2PR4 FT-0634441 L-Homocysteinesulfinic acid SCHEMBL10135851 BDBM86201 NCGC00163274-02 2686-70-6 CHEMBL1516176 FT-0639107 PDSP2_001256 AC1Q5QML [ Show all ]
Inchi Key	PDNJLMZEGXHSCU-VKHMYHEASA-N
Inchi ID	InChI=1S/C4H9NO4S/c5-3(4(6)7)1-2-10(8)9/h3H,1-2,5H2,(H,6,7)(H,8,9)/t3-/m0/s1
PubChem CID	75896
ChEMBL	N/A
IUPHAR	N/A
BindingDB	86201
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID12649361	BindingDB

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